Publications by authors named "M Ridderstrale"
Article Synopsis
- Cardiovascular disease (CVD) is the top cause of illness and death worldwide, largely due to atherosclerosis, which affects about two-thirds of CVD patients.
- Atherosclerosis develops over many years, offering a chance for preventive measures to avoid serious events like heart attacks and strokes, especially since early signs are seen in younger people.
- There's a need for a shift in focus from treating advanced CVD to detecting it early; research should explore using precision medicine and biomarkers to identify atherosclerosis sooner and assess if this could lower healthcare costs globally.
Context: The role of glucagon-like peptide-1 (GLP-1) in type 2 diabetes (T2D) and obesity is not fully understood.
Objective: We investigate the association of cardiometabolic, diet, and lifestyle parameters on fasting and postprandial GLP-1 in people at risk of, or living with, T2D.
Methods: We analyzed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) cohorts, cohort 1 (n = 2127) individuals at risk of diabetes; cohort 2 (n = 789) individuals with new-onset T2D.
Precision medicine for cardiometabolic disease: a framework for clinical translation.
Lancet Diabetes Endocrinol
November 2023
Cardiometabolic disease is a major threat to global health. Precision medicine has great potential to help to reduce the burden of this common and complex disease cluster, and to enhance contemporary evidence-based medicine. Its key pillars are diagnostics; prediction (of the primary disease); prevention (of the primary disease); prognosis (prediction of complications of the primary disease); treatment (of the primary disease or its complications); and monitoring (of risk exposure, treatment response, and disease progression or remission).
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- The study examines genetic regulation of mRNA, proteins, and metabolites in blood samples from over 3,000 people, revealing that many genetic variants influence multiple molecular traits.* -
- It finds that there's a strong genetic connection between gene expression and protein levels (66.6%), and shows broad connections across various tissues, highlighting the shared genetic basis for different traits.* -
- By creating networks of known genetic variants, the research indicates that these variants are more frequently linked to gene expression rather than other molecular traits, helping to clarify the mechanisms behind genetic associations.*