FBP1 controls liver cancer evolution from senescent MASH hepatocytes.

Hepatocellular carcinoma (HCC) originates from differentiated hepatocytes undergoing compensatory proliferation in livers damaged by viruses or metabolic-dysfunction-associated steatohepatitis (MASH). While increasing HCC risk, MASH triggers p53-dependent hepatocyte senescence, which we found to parallel hypernutrition-induced DNA breaks. How this tumour-suppressive response is bypassed to license oncogenic mutagenesis and enable HCC evolution was previously unclear.

A novel magnetic-assisted ionic liquid-based microextraction method (MA-ILBME): Specific design system for sensitive spectrophotometric analysis of paracetamol as a pharmaceutical pollutant in environmental samples.

Monitoring paracetamol levels in environmental samples is essential, as this widely used pharmaceutical can degrade water quality and adversely affect both ecosystems and human health. To address this issue, a novel, simple, sensitive, and accurate method has been developed. This method employs a functionalized ionic liquid, 2-(4-hydroxybenzyl)hydrazinium chloride ([HBH][Cl]), specifically designed to structurally mimic paracetamol and function as a complexing agent.

Association between serum hypertriglyceridemia and hematological indices: data mining approaches.

Background: High triglyceride (TG) affects and is affected of other hematological factors. The determination of serum fasted triglycerides concentrations, as part of a lipid profile, is crucial key point in hematological factors and significantly affect various systemic diseases. This study was carried out to assess the potential relation between the concentration of TG and hematological factors.

Strategic scheduling of the electric vehicle-based microgrids under the enhanced particle swarm optimization algorithm.

With increasing worldwide attention on environmental sustainability, microgrids that harness renewable sources have become more prominent. The changing characteristics of renewable energy sources and energy demand's unpredictable patterns might cause disruptions in the sustainable working of microgrids. Moreover, EVs (electric vehicles), being dynamic loads, might significantly affect the security administration of the microgrid.

Investigating the resilience of kidneys in rats exposed to chronic partial sleep deprivation and circadian rhythm disruption as disruptive interventions.

Sleep is a vital biological function that significantly influences overall health. While sleep deprivation (SD) and circadian rhythm disruption are known to negatively impact various organs, their specific effects on kidney function remain understudied. This study aimed to investigate the impact of chronic partial sleep deprivation and circadian rhythm disruption on renal function in rats, providing insights into the relationship between sleep disturbances and kidney health.