The Benefit of Combining Docetaxel with Androgen Deprivation Therapy in Localized and Metastatic Hormone-sensitive Prostate Cancer is Predicted by ERG Expression: An Analysis of Two GETUG Phase 3 Trials.

Background And Objective: Docetaxel has become a standard component of care for advanced prostate cancer (PC); however, its benefits are not universal among patients. A subset of PC cases exhibit TMPRSS2-ERG gene fusion, resulting in ERG overexpression in tumors. Our aim was to assess biomarkers for docetaxel efficacy in men with hormone-sensitive PC (HSPC).

Curcumin attenuates brain aging by reducing apoptosis and oxidative stress.

Brain aging is a physiological event, and oxidative stress and apoptosis are involved in the natural aging process of the brain. Curcumin is a natural antioxidant with potent anti-aging and neuroprotective properties. Therefore, we investigated the protective effects of curcumin on brain apoptosis and oxidative stress, brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF) in aged rats.

Protective Role of Short-term Aerobic Exercise Against Zinc Oxide Nanoparticles-Induced Cardiac Oxidative Stress Via Possible Changes of Apelin, Angiotensin II/Angiotensin II Type I Signalling Pathway.

This study examined the protective role of short-term aerobic exercise on ZnO NPs-induced cardiac oxidative stress and possible changes of apelin, angiotensin II (AngII) and angiotensin II type I receptor (AT1R) signalling pathway. Thirty-five male Wistar rats were randomized into five groups of seven rats, including control, saline, ZnO NPs, exercise and exercise + ZnO NPs groups. The animal in ZnO NPs and exercise + ZnO NPs groups received 1 mg/kg of ZnO NPs.

Contribution of anthropogenic pollutant sources to greenhouse gas emissions: a case study from a developing country.

Anthropogenic greenhouse gas (GHG) emissions are the primary cause of climate change, one of the biggest challenges for humankind. To tackle this problem, the international community is looking for ways to reduce GHG emissions. To create reduction strategies in a city/province/country, there is a need for an inventory that provides emission amounts from different sectors.

Laying performance, egg quality, fertility, nutrient digestibility, digestive enzymes activity, gut microbiota, intestinal morphology, antioxidant capacity, mucosal immunity, and cytokine levels in meat-type Japanese quail breeders fed different phytogenic levels.

A total of 180 female Japanese quail breeders were allocated to 5 treatments with 6 replicates of 6 birds and fed a diet supplemented with 0, 125, 250, 500, or 1000 mg/kg of a phytogenic feed additive (PFA) in a 9-wk experiment. Egg weight, feed efficiency, shell breaking strength and calcium content, specific gravity, Haugh unit, and percentages of fertile eggs increased with increasing PFA levels (P < 0.05).