Publications by authors named "M Revuelta"
Noise-induced hearing loss (NIHL) is responsible for significant adverse effects on cognition, quality of life and work, social relationships, motor skills, and other psychological aspects. The severity of NIHL depends on individual patient characteristics, sound intensity, and mainly the duration of sound exposure. NIHL leads to the production of a reactive oxygen (ROS) inflammatory response and the activation of apoptotic pathways, DNA fragmentation, and cell death.
View Article and Find Full Text PDFSex Differences in Chronic Postsurgical Pain after Open Thoracotomy.
J Cardiothorac Vasc Anesth
December 2024
Study Objective: To determine the incidence of chronic postsurgical pain (CPSP) in women after open thoracotomy. Secondary objectives were to compare relevant patient and procedural variables between women and men.
Design: Observational cohort study.
Article Synopsis
- - Voltage-gated ion channels are crucial for maintaining membrane potential and regulating electrical signals in neurons, with voltage-gated potassium channels (K) being particularly important for neuronal excitability.
- - High levels of reactive oxygen species (ROS) in the aging brain can impact K channels, contributing to aging and neurodegeneration, especially in conditions like Alzheimer's, Parkinson's, and Huntington's diseases.
- - The review highlights specific K channels affected in these disorders (K1, K2.1, K3, K4, K7) and suggests that modulators of these channels may serve as potential therapeutic targets to prevent or treat neurodegenerative diseases.
Article Synopsis
- The study investigates the distinct regions of the germinal center (GC)—the dark zone (DZ) and light zone (LZ)—which are crucial for B-cell expansion and antibody maturation, yet lack a clear understanding of their immune composition differences.
- Researchers discovered specific DNA damage responses and chromatin features that explain why T-cells are excluded from the DZ region, providing insights into its immune-repulsive characteristics.
- The findings highlight the role of the ATR kinase in regulating responses in the DZ, suggesting that targeting ATR could enhance immunotherapy effectiveness for aggressive types of lymphoma like Diffuse Large B-cell Lymphomas (DLBCL).
Unlabelled: Exportin-1 (XPO1), the main soluble nuclear export receptor in eukaryotic cells, is frequently overexpressed in diffuse large B-cell lymphoma (DLBCL). A selective XPO1 inhibitor, selinexor, received approval as single agent for relapsed or refractory (R/R) DLBCL. Elucidating the mechanisms by which XPO1 overexpression supports cancer cells could facilitate further clinical development of XPO1 inhibitors.
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