Publications by authors named "M Reid Bowes"
Systemic lupus erythematosus is a remitting relapsing autoimmune disease characterized by autoantibody production and multi-organ involvement. T cell epigenetic dysregulation plays an important role in the pathogenesis of lupus. We have previously demonstrated upregulation of the key epigenetic regulator EZH2 in CD4 T cells isolated from lupus patients.
View Article and Find Full Text PDFWater quality monitoring at high temporal frequency provides a detailed picture of environmental stressors and ecosystem response, which is essential to protect and restore lake and river health. An effective monitoring network requires knowledge on optimal monitoring frequency and data variability. Here, high-frequency hydrochemical datasets (dissolved oxygen, pH, electrical conductivity, turbidity, water temperature, total reactive phosphorus, total phosphorus and nitrate) from six UK catchments were analysed to 1) understand the lowest measurement frequency needed to fully capture the variation in the datasets; and 2) investigate bias caused by sampling at different times of the day.
View Article and Find Full Text PDFAntimicrobial resistance (AMR) is a global health hazard. Although clinical and agricultural environments are well-established contributors to the evolution and dissemination of AMR, research on wastewater treatment works (WwTWs) has highlighted their potential role as disseminators of AMR in freshwater environments. Using metagenomic sequencing and analysis, we investigated the changes in resistomes and associated mobile genetic elements within untreated wastewater influents and treated effluents of five WwTWs, and sediments collected from corresponding river environments in Oxfordshire, UK, across three seasonal periods within a year.
View Article and Find Full Text PDFArticle Synopsis
- A study investigated the potential benefits of methotrexate, an antirheumatic drug, in treating knee osteoarthritis (KOA) pain through a multicenter, double-blind, placebo-controlled trial involving 207 participants.
- Participants were randomly assigned to receive either methotrexate or a placebo for 12 months while continuing their usual pain relief medications, with a primary focus on assessing average knee pain at 6 months.
- Results indicated that the methotrexate group experienced a significant decrease in knee pain compared to the placebo group, suggesting methotrexate may provide symptomatic relief for KOA.
Article Synopsis
- - The study investigates the transferability of a Bayesian Belief Network (BBN) model designed to simulate monthly stream phosphorus concentrations, applying it to three different catchments with varying hydrology and land use to assess its predictive capabilities.
- - The original BBN model showed strong performance in accurately simulating phosphorus and flow values in poorly and moderately drained catchments, but struggled in groundwater-dominated areas; modifications, like incorporating additional groundwater inputs, led to improved model accuracy.
- - A sensitivity analysis allowed the identification of unnecessary variables, ultimately resulting in an enhanced BBN model that demonstrates better generalization and application across diverse catchments.