Publications by authors named "M Reguera-Gomez"
Article Synopsis
- Cryptococcus neoformans (Cn) is a dangerous fungus that can lead to severe brain infections, especially in people with weakened immune systems; the study explores the role of the cytokine IL-6 in fighting this infection.* -
- Mice lacking IL-6 (knock-out) showed increased mortality and higher fungal levels in the brain and blood compared to wild-type and IL-6 supplemented groups, indicating IL-6's importance in controlling Cn infection.* -
- The presence of IL-6 led to a stronger immune response in the brain, characterized by activated microglia that help fight off the fungus, while its absence resulted in fewer defensive responses and potential neurodegeneration.*
Cryptococcus neoformans (Cn) is an opportunistic fungus that causes severe central nervous system (CNS) disease in immunocompromised individuals. Brain parenchyma invasion requires fungal traversal of the blood-brain barrier. In this study, we describe that Cn alters the brain endothelium by activating small GTPase RhoA, causing reorganization of the actin cytoskeleton and tight junction modulation to regulate endothelial barrier permeability.
View Article and Find Full Text PDFInnovative and potential treatments for fungal central nervous system infections.
Curr Opin Microbiol
December 2023
Fungal infections of the central nervous system (FI-CNS) are a problematic and important medical challenge considering that those most affected are immunocompromised. Individuals with systemic cryptococcosis (67-84%), candidiasis (3-64%), blastomycosis (40%), coccidioidomycosis (25%), histoplasmosis (5-20%), mucormycosis (12%), and aspergillosis (4-6%) are highly susceptible to develop CNS involvement, which often results in high mortality (15-100%) depending on the mycosis and the affected immunosuppressed population. Current antifungal drugs are limited, prone to resistance, present host toxicity, and show reduced brain penetration, making FI-CNS very difficult to treat.
View Article and Find Full Text PDFPalmitoylethanolamide shows limited efficacy in controlling cerebral cryptococcosis .
Antimicrob Agents Chemother
October 2023
() is an encapsulated neurotropic fungal pathogen and the causative agent of cryptococcal meningoencephalitis (CME) in humans. Recommended treatment for CME is Amphotericin B (AmpB) and 5-fluorocytosine (5-FC). Though effective, AmpB has displayed numerous adverse side effects due to its potency and nephrotoxicity, prompting investigation into alternative treatments.
View Article and Find Full Text PDFExecutive summary consensus statement of imported diseases group (GEPI) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) and the Spanish Society of Tropical Medicine and International Health (SETMSI), on the diagnostic and treatment of imported schistosomiasis.
Enferm Infecc Microbiol Clin (Engl Ed)
October 2023
Article Synopsis
- * The Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) and the Spanish Society of Tropical Medicine and International Health (SEMTSI) collaborated to create a consensus document for effectively screening, diagnosing, and treating schistosomiasis.
- * Experts from both societies contributed to the document by identifying critical questions and forming evidence-based recommendations, which were then approved by their members.