Publications by authors named "M Regazzi Bonora"
Article Synopsis
- - p66Shc is an adaptor protein crucial for regulating cellular functions including signaling pathways, mitochondrial activity, and the production of reactive oxygen species (ROS), with its location shifting to mitochondria under oxidative stress.
- - The protein is also implicated in mitochondria-associated membranes (MAM), which play a role in key cellular processes like calcium balance, apoptosis (cell death), and autophagy (cell cleaning), suggesting p66Shc's involvement in determining cell fate.
- - This study investigates the distribution of p66Shc in different parts of mouse liver tissue and HepG2 cells, demonstrating a significant presence of p66Shc in MAM under both normal and oxidative stress conditions.
Mitochondria are considered one of the main sites of reactive oxygen species (ROS) production in the eukaryotic cells. For this reason, mitochondrial dysfunction associated with increased ROS production underlies various pathological conditions as well as promotes aging. Chronically increased rates of ROS production contribute to oxidative damage to macromolecules, i.
View Article and Find Full Text PDFCharged particle radiotherapy for thyroid cancer. A systematic review.
Crit Rev Oncol Hematol
October 2024
Article Synopsis
- The use of external beam radiotherapy (EBRT) for thyroid cancer treatment is debated because there isn't a lot of strong data.
- Some studies suggest that EBRT can help people with high-risk cases of thyroid cancer when it's used with surgery and chemotherapy.
- Newer treatments like proton therapy and Boron Neutron Capture Therapy (BNCT) could be helpful, but more research is needed to understand how they work best.
Pulsed electromagnetic fields (PEMFs) are recognized for their potential in regenerative medicine, offering a non-invasive avenue for tissue rejuvenation. While prior research has mainly focused on their effects on bone and dermo-epidermal tissues, the impact of PEMFs on nervous tissue, particularly in the context of neuropathy associated with the diabetic foot, remains relatively unexplored. Addressing this gap, our preliminary in vitro study investigates the effects of complex magnetic fields (CMFs) on glial-like cells derived from mesenchymal cell differentiation, serving as a model for neuropathy of the diabetic foot.
View Article and Find Full Text PDFMitochondrial metabolism plays a central role in the regulation of hematopoietic stem cell (HSC) biology. Mitochondrial fatty acid oxidation (FAO) is pivotal in controlling HSC self-renewal and differentiation. Herein, we discuss recent evidence suggesting that NADPH generated in the mitochondria can influence the fate of HSCs.
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