Coupled infectious disease and behavior dynamics. A review of model assumptions.

To comprehend the dynamics of infectious disease transmission, it is imperative to incorporate human protective behavior into models of disease spreading. While models exist for both infectious disease and behavior dynamics independently, the integration of these aspects has yet to yield a cohesive body of literature. Such an integration is crucial for gaining insights into phenomena like the rise of infodemics, the polarization of opinions regarding vaccines, and the dissemination of conspiracy theories during a pandemic.

Who influences lower-status individuals more: People of higher-status outgroups or people of their lower-status ingroup? Examining the difference between matters of opinion and matters of fact.

People are influenced by members of high-status groups and members of their ingroup. These principles of "status orientation" and "ingroup orientation" can imply opposing forces for people of lower status. Are lower-status individuals more influenced by members of higher-status outgroups or by members of their lower-status ingroup? Engaging status characteristics theory and self-categorization theory, we predict that status orientation is relatively stronger on questions about facts, which have an objectively correct answer, whereas ingroup orientation is stronger when it comes to 'opinion questions' that have no objectively correct answer.

A randomized controlled study of neoadjuvant metformin with chemotherapy in nondiabetic breast cancer women: The METNEO study.

Aims: Clinical data demonstrate that metformin exhibits antiproliferative, proapoptotic and antimetastatic actions. Here, correlative molecular studies were undertaken to determine the roles of transmembrane tumour necrosis factor-related apoptosis-inducing ligand death receptors (DRs) and CD133, a glycoprotein biomarker of breast cancer (BC) stem cells, in the advantageous action of metformin on pathological and clinical outcomes in BC patients on neoadjuvant chemotherapy.

Methods: We randomly assigned 70 nondiabetic BC patients in a 1:1 ratio to either neoadjuvant AC-T chemotherapy (4 cycles of adriamycin 60 mg/m and cyclophosphamide 600 mg/m, followed by 12 cycles of weekly paclitaxel 80 mg/m) or AC-T with adjunct metformin (850 mg twice/day).

Gestationally administered RAS modulators reprogram endotoxic cardiovascular and inflammatory profiles in adult male offspring of preeclamptic rats.

Previous studies showed that preeclampsia (PE) amplifies cardiovascular dysfunction induced by endotoxemia in adult male, but not female, offspring. Here, we asked if such aggravated endotoxic insult could be nullified by modulators of the renin-angiotensin system (RAS). PE was induced by gestational administration of N-nitro-L-arginine methyl ester(L-NAME, a nitric oxide synthase inhibitor).

Suppression by central adenosine A3 receptors of the cholinergic defense against cardiovascular aberrations of sepsis: role of PI3K/MAPKs/NFκB signaling.

Despite the established role of peripheral adenosine receptors in sepsis-induced organ dysfunction, little or no data is available on the interaction of central adenosine receptors with sepsis. The current study tested the hypothesis that central adenosine A3 receptors (A3ARs) modulate the cardiovascular aberrations and neuroinflammation triggered by sepsis and their counteraction by the cholinergic antiinflammatory pathway. Sepsis was induced by cecal ligation and puncture (CLP) in rats pre-instrumented with femoral and intracisternal (i.