Publications by authors named "M Redston"
The aim of this study was to investigate whether interventions to discontinue or down-titrate heart failure (HF) pharmacotherapy are feasible and associated with risks in older people. A systematic review and meta-analysis were conducted according to PRISMA 2020 guidelines. Electronic databases were searched from inception to 8 March 2023.
View Article and Find Full Text PDFObjectives: The Drug Burden Index (DBI) calculates a person's exposure to anticholinergic and sedative medications. We aimed to review randomized controlled trials (RCTs) of deprescribing interventions that reported the DBI as an outcome, their characteristics, effectiveness in reducing the DBI, and impact on other outcomes.
Design: Systematic review with meta-analysis.
Article Synopsis
- The study investigates the occurrence of pagetoid spread in esophageal squamous cell carcinomas (ESCC), a condition previously mainly associated with esophageal adenocarcinoma (EAC), through seven identified cases from multiple pathology archives.
- Researchers compared the clinical and morphological details of pagetoid spread in ESCC cases to those in EAC to highlight differences and similarities, noting that pagetoid spread in ESCC is underreported.
- The findings reveal that most patients with ESCC exhibiting pagetoid spread were older adults, predominantly female, and that distinct immunohistochemical markers (like positive p40 and p63) may aid in identifying these cases.
Objective: To describe the clinical, endoscopic, histologic, and treatment outcomes of Helicobacter heilmannii (H. heilmannii) associated gastritis in children in the New England region of the United States.
Methods: Retrospective study of children (1-18 years) with H.