Cyanocobalamin-loaded dissolving microneedles diminish skin inflammation in vivo.

Inflammatory diseases of the skin have a considerable high prevalence worldwide and negatively impact the patients' quality of life. First-line standard therapies for these conditions inherently entail important side effects when used long-term, particularly complicating the management of chronic cases. Therefore, there is a need to develop novel therapeutic strategies to offer reliable alternative treatments.

Variations, trends and forecast models for the airborne Olea europaea pollen season in Tétouan (NW of Morocco).

Olea europaea L. is an emblematic tree plantation of the Mediterranean basin and one of the main sources of allergenic pollen. In this study, we examined variations in airborne Olea pollen season, trends and built forecast models based on multiple regression analysis over a 13-year period (2008-2019, 2022) in NW of Morocco (Tétouan), focusing on start date of pollination (SDP), end date of pollination (EDP), peak date (PD), and pre-peak pollen Integral (PPI).

Impact of nursing interventions on the prevention of ocular surface disorders in critical care patients: A systematic review.

Background: Intensive care unit (ICU) patients are at an increased risk of ocular surface injuries because of various factors such as reduced tear production and impaired protective mechanisms. Despite the significance of ocular care in ICU settings, there is a lack of consensus on effective interventions, leading to inadequate prevention of ocular surface disease (OSD).

Aim: This systematic review aimed to assess the effectiveness of nursing eye care in preventing OSD in ICU patients.

Characterization of an extremophile bacterial acid phosphatase derived from metagenomics analysis.

Acid phosphatases are enzymes that play a crucial role in the hydrolysis of various organophosphorous molecules. A putative acid phosphatase called FS6 was identified using genetic profiles and sequences from different environments. FS6 showed high sequence similarity to type C acid phosphatases and retained more than 30% of consensus residues in its protein sequence.

Cyclosporin A-loaded dissolving microneedles for dermatitis therapy: Development, characterisation and efficacy in a delayed-type hypersensitivity in vivo model.

Several drugs can be used for treating inflammatory skin pathologies like dermatitis and psoriasis. However, for the management of chronic and long-term cases, topical administration is preferred over oral delivery since it prevents certain issues due to systemic side effects from occurring. Cyclosporin A (CsA) has been used for this purpose; however, its high molecular weight (1202 Da) restricts the diffusion through the skin structure.