Evaluation of Colombian Crops Fibrous Byproducts for Potential Applications in Sustainable Building Acoustics.

Local production of construction materials is a valuable tool for improving the building sector sustainability. In this sense, the use of lignocellulosic fibers from local species becomes an interesting alternative to the development of such materials. As it is thought that the properties of fiber-based materials are dependent on the fibers properties, the knowledge of such properties is fundamental to promote materials development.

Action of Pitolisant on the stimulant and rewarding effects of cocaine in mice.

Previous studies have demonstrated that the histamine H3 receptor inverse agonist thioperamide potentiates the stimulant and rewarding effects of cocaine. However, these potentiating effects of thioperamide do not necessarily result from H3 receptor blockade since thioperamide is an imidazole-based compound capable of enhancing plasma cocaine concentrations by blocking cytochrome P450 activity. In contrast, Pitolisant is a non-imidazole H3 receptor inverse agonist that has already been tested in clinical trials but it remains to be determined whether this compound also potentiates the behavioral effects of cocaine.