The Triad of Blood-Brain Barrier Integrity: Endothelial Cells, Astrocytes, and Pericytes in Perinatal Stroke Pathophysiology.

Pediatric stroke, a significant cause of long-term neurological deficits in children, often arises from disruptions within neurovascular unit (NVU) components. The NVU, a dynamic ensemble of astrocytes, endothelial cells, pericytes, and microglia, is vital for maintaining cerebral homeostasis and regulating vascular brain development. Its structural integrity, particularly at the blood-brain barrier (BBB), depends on intercellular junctions and the basement membrane, which together restrict paracellular transport and shield the brain from systemic insults.

Pain and anxiety due to venipuncture in the adult population.

Aim: To evaluate anxiety and pain induced by venipuncture and its statistical association with sociodemographic variables and history of previous venipuncture in the adult population.

Method: An observational, cross-sectional, quantitative and analytical study was conducted. A questionnaire was used to collect data on sociodemographic variables and variables related to pain and anxiety induced by venipuncture in the adult population attending a Mexican ambulatory care center.

Integration of Complementary Medicine in Geriatric Nursing Homes: A Prospective Comparative Observational Study.

Introduction A healthy lifestyle is considered to be an important factor for healthy aging. Kneipp therapy (KT) includes a combination of hydrotherapy, herbal medicine, mind-body medicine, physical activities and healthy nutrition. In this study, we investigated the effectiveness of KT care on activities of daily living, health and quality of life in residents of nursing homes.

New Method of Early RRMS Diagnosis Using OCT-Assessed Structural Retinal Data and Explainable Artificial Intelligence.

Purpose: The purpose of this study was to provide the development of a method to classify optical coherence tomography (OCT)-assessed retinal data in the context of automatic diagnosis of early-stage multiple sclerosis (MS) with decision explanation.

Methods: The database used contains recordings from 79 patients with recently diagnosed relapsing-remitting multiple sclerosis (RRMS) and no history of optic neuritis and from 69 age-matched healthy control subjects. Analysis was performed on the thicknesses (average right and left eye value and inter-eye difference) of the macular retinal nerve fiber layer (mRNFL), macular ganglion cell layer (mGCL), macular inner plexiform layer (mIPL), and macular inner retinal complex layer (mIRL), dividing the macular area into six analysis zones.

Attitudes toward healthy nutrition in Germany - results from an online-representative cross-sectional survey.

Introduction: Nutrition plays a crucial role in current German public health strategies. While sociodemographic differences in nutrition have been extensively studied, recent data specific to Germany remains limited.

Methods: An online-representative cross-sectional survey was conducted in 2022 among German-speaking adults aged 18-75 using a Computer Assisted Web Interview (CAWI) format.