Publications by authors named "M Rayar"
Background: Childhood obesity can result in adverse health outcomes. The objectives of this study were to describe the prevalence of obesity and determine the association between obesity at cancer diagnosis and event-free survival (EFS) and overall survival (OS) in children diagnosed with cancer in Canada.
Methods: The authors conducted a retrospective cohort study using the Cancer in Young People in Canada database, including all children with newly diagnosed cancer aged 2-18 years across Canada from 2001 to 2020.
Objective: Recently, the pig liver model perfused ex vivo using a normothermic machine perfusion (NMP) has been proposed as a suitable model to study xenobiotic metabolism and biliary excretion. The aim of our study is to describe the metabolism of NPS such as cathinones (with a focus on 4-Cl-PVP and eutylone) in blood and bile, using a normothermic perfused pig liver model.
Methods: Livers (n = 4) from male large white pigs, 3-4 months of age and weighing approximately 75-80 kg, were harvested and reperfused onto an NMP (LiverAssist®, XVIVO) using autologous whole blood at 38 °C.
Article Synopsis
- - The study investigates how socioeconomic status (SES) and healthcare access affect the diagnosis and outcomes of childhood acute lymphoblastic leukemia (ALL) in Canada, examining data from 2001 to 2019 for children under 15 years old.
- - Researchers analyzed the connections between neighborhood income levels and distance to treatment centers in relation to high-risk features at diagnosis, treatment timeliness, and survival rates using multivariable analyses and Cox proportional hazards models.
- - Results show no significant link between income or distance from treatment centers and most outcomes; however, children in higher income brackets experienced better event-free survival, while distance to treatment was associated with greater incidence of central nervous system disease at diagnosis and differences in treatment timelines.
Biliary complications remain a real issue in liver transplantation (LT). Despite meta-analyses, the anastomosis technique, especially the use of biliary drain as T-Tube drain (TT) or transcystic drain, remains controversial. This study conducted by the ARCHET research group examine the incidence and types of biliary complications (BC) after LT according to the presence or absence of a biliary drain.
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- Acute liver failure (ALF) often requires ICU care and may need emergency liver transplants, and high-volume plasma exchange (HVPE) could help improve survival rates without a transplant.
- A study analyzed 120 HVPE sessions in 50 ALF patients, noting that paracetamol was the leading cause of ALF, and various blood parameters were affected during the procedures.
- Results showed that severe adverse effects, particularly severe alkalosis, hypotension, and hypocalcemia, were common, with specific blood pH levels and paracetamol as significant predictors for survival after 21 days.