COVID-19 vaccine associated demyelination & its association with MOG antibody.

Background: ChAdOx1-S (Covishield™/Vaxzervria, AstraZeneca) and BBV152 (Covaxin) SARS-CoV-2 vaccines are proven to be safe and effective, but rare complications have been reported.

Objective: To describe reports of central nervous system (CNS) demyelination following ChAdOx1-S and BBV152 vaccinations.

Methods & Results: We report 29 (17 female; mean 38 years) cases of CNS demyelination; twenty-seven occurred in temporal association with ChAdOx1-S vaccine; two in association with BBV152 vaccine.