Enhanced brain tumor classification using graph convolutional neural network architecture.

The Brain Tumor presents a highly critical situation concerning the brain, characterized by the uncontrolled growth of an abnormal cell cluster. Early brain tumor detection is essential for accurate diagnosis and effective treatment planning. In this paper, a novel Convolutional Neural Network (CNN) based Graph Neural Network (GNN) model is proposed using the publicly available Brain Tumor dataset from Kaggle to predict whether a person has brain tumor or not and if yes then which type (Meningioma, Pituitary or Glioma).

A Synthetic Carbohydrate-Protein Conjugate Vaccine Candidate against Serotype K2.

causes pneumonia and liver abscesses in humans worldwide and contains virulence factor capsular polysaccharides and lipopolysaccharides linked to the cell wall. Although capsular polysaccharides are good antigens for vaccine production and capsular oligosaccharides conjugate vaccines are proven effective against infections caused by encapsulated pathogens, there is still no vaccine available. One obstacle is that the capsular polysaccharide of a dominated serotype K2 is difficult to synthesize chemically due to the three 1,2- linkages in its structure.

Synthesis of Asymmetric -Glycans as Common Core Substrates for Structural Diversification through Selective Enzymatic Glycosylation.

-glycans on the cell surface provide distinct signatures that are recognized by different glycan-binding proteins (GBPs) and pathogens. Most glycans in humans are asymmetric and isomeric, yet their biological functions are not well understood due to their lack of availability for studies. In this work, we have developed an improved strategy for asymmetric -glycan assembly and diversification using designed common core substrates prepared chemically for selective enzymatic fucosylation and sialylation.

Synthesis, antitubercular and anticancer activity of new Baylis-Hillman adduct-derived -cinnamyl-substituted isatin derivatives.

Baylis-Hillman adduct-derived -cinnamyl-substituted isatin derivatives were synthesized and evaluated for their antitubercular activity on HRv strain ATCC 27294 by agar dilution method. Anticancer activity for the same compounds was also screened on four different cell lines: Chinese hamster ovary (CHO cells), Colo 205 (human colon cancer), Sup-T1 (human lymphoma) and C6 glioma (rat glioma) by MTT assay method. The compounds (-) have shown significant activity against strain and the compound has shown specific cytotoxic activity.