Evaluation of diflubenzuron-verapamil combination strategy for eco-safe management of .

Introduction: , the vector of multiple arboviral diseases, is a prime health concern worldwide. The surge in borne diseases emphasizes the urgent need for efficient vector control measures. Synthetic pesticides used traditionally, however, present environmental concerns and issues like resistance development, causing the use of higher chemical doses.

Repurposing fluvoxamine as an inhibitor for NUDT5 in breast cancer cell: an in silico and in vitro study.

Unlabelled: Drug repurposing is necessary to accelerate drug discovery and meet the drug needs. This study investigated the possibility of using fluvoxamine to inhibit the cellular metabolizing enzyme NUDT5 in breast cancer. Computational and experimental techniques were used to evaluate the structural flexibility, binding stability, and chemical reactivity of the drugs.

Effect of protonation induced distortions on the spectral properties and electronic structure of Octaphenylporphyrins: UV-vis, electrochemical, VT-NMR and ab initio studies.

The extent of conformational alteration of the porphyrin macrocycle during the course of protonation was observed, both experimentally and theoretically. For synthesized β-substituted octaphenylporphyrin (OPP) ring systems this macrocyclic distortions have been investigated by spectroscopic and computational analysis. Protonation induced nonplanarity in macrocyclic system is experimentally observed in a single step during spectrophotometric titration.

Cocktail vaccine for the management of and .

Introduction: Globally, ticks rank second only to mosquitoes as vectors of deadly pathogens affecting humans and first in transmitting animal pathogens, presenting a significant challenge to human wellness and sustainability of livestock-based industries. Traditional tick control via chemical acaricides impacts on the environment and has led to the emergence of multi-acaricide-resistant tick populations. Use of immunoprophylactic, along with other components of integrated tick management, holds the potential to mitigate tick infestations in a sustainable manner.