In vitro effects of somatostatin on red cell filterability measured by three methods.

Somatostatin is an ubiqutary neuropeptide and hormone which has been reported to exert hemodynamic effects and to bind to receptors on the red cell membrane. We investigated its effects on red cell deformability by three filtration methods: (a) filtration of red cells resuspended at hematocrit 8% in Tris-Albumin-Glucose buffer under atmospheric pressure; (b) filtration of red cells resuspended at hematocrit on native plasma at 8% hematocrit under a negative pressure of 5 cm of water; (c) filtrability of whole blood under a negative pressure of 20 cm of water. Aprotinin (Antagosan*) was added to the different suspensions in order to avoid rapid destruction of somatostatin.

[Sensitivity curves of multiply resistant corynebacteria JK and D2].

Corynebacteria groups JK and D2 are opportunistic pathogens. They are sometimes responsible for severe infections, especially in immunocompromised patients. They are resistant to many antibiotics.