Publications by authors named "M Ratajska"
Background: The mRNA splicing is regulated on multiple levels, resulting in the proper distribution of genes' transcripts in each cell and maintaining cell homeostasis. At the same time, the expression of alternative transcripts can change in response to underlying genetic variants, often missed during routine diagnostics.
Aim: The main aim of this study was to define the frequency of aberrant splicing in BRCA1 and BRCA2 genes in blood RNA extracted from ovarian cancer patients who were previously found negative for the presence of pathogenic alterations in the 25 most commonly analysed ovarian cancer genes, including BRCA1 and BRCA2.
Article Synopsis
- Melanoma is a tough skin cancer that often outsmarts the immune system, but immune checkpoint inhibitors (ICIs) like anti-PD1 can help reactivate immune responses against it.
- Despite the potential of ICIs, only a small number of patients respond effectively, with unclear reasons for resistance in others.
- This study analyzed melanoma tissues from patients before anti-PD1 treatment, finding that responders had higher immune scores and a greater presence of beneficial immune cells compared to non-responders, along with differences in gene expression patterns related to cancer aggressiveness.
Unlabelled: Several ovarian cancer susceptibility genes have been discovered, but more are likely to exist. In this study, we aimed to analyze knowledge-based selected genes, that is, BARD1, PRDM9, RCC1, and RECQL, in which pathogenic germline variants have been reported in patients with breast and/or ovarian cancer. As deep sequencing of DNA samples remains costly, targeted next-generation sequencing of DNA pools was utilized to screen the exons of BARD1, PRDM9, RCC1, and RECQL in approximately 400 Polish ovarian cancer cases.
View Article and Find Full Text PDFBackground: Liquid biopsy is a minimally invasive collection of a patient body fluid sample. In oncology, they offer several advantages compared to traditional tissue biopsies. However, the potential of this method in endometrial cancer (EC) remains poorly explored.
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