MicroRNA dynamics, PTEN/PI3K/AKT signaling, and their relationship to breast cancer: prospects for pharmaceuticals and natural product application.

Background: Globally, Breast Cancer (BC) is the most frequent cancer in women and has a major negative impact on the physical and emotional well-being of its patients as well as one of the most common cancers to be diagnosed. Numerous studies have been published to identify various molecular pathways, including PI3K/AKT/PTEN. Moreover, growing evidence suggests that miRNAs have been found to play a vital role in the growth and carcinogenesis of tumors.

Impact of Kidney Disease in Patients Undergoing Catheter Directed Interventions for Intermediate to High-Risk Pulmonary Embolism.

Background: Catheter-directed interventions (CDIs) for pulmonary embolism (PE) continue to evolve. However, due to the paucity of data, their use has been limited in patients with underlying kidney disease.

Methods: The National Readmission Database (2016-2020) was utilized to identify intermediate to high-risk PE (IHR-PE) patients requiring CDI (thrombectomy, thrombolysis, and ultrasound-assisted thrombolysis).

One health assessment of farmers' knowledge, attitudes, and practices (KAPs) on zoonoses in Bangladesh.

In Bangladesh, farming serves as a key livelihood, leading to a higher risk of zoonotic diseases due to frequent animal interactions and traditional practices. The study aimed to assess the knowledge, attitudes, and practices of livestock farmers regarding zoonotic disease outbreaks. A cross-sectional study was conducted with 658 livestock farmers from randomly selected regions in Bangladesh from April to June 2024.

An automated privacy-preserving self-supervised classification of COVID-19 from lung CT scan images minimizing the requirements of large data annotation.

This study presents a novel privacy-preserving self-supervised (SSL) framework for COVID-19 classification from lung CT scans, utilizing federated learning (FL) enhanced with Paillier homomorphic encryption (PHE) to prevent third-party attacks during training. The FL-SSL based framework employs two publicly available lung CT scan datasets which are considered as labeled and an unlabeled dataset. The unlabeled dataset is split into three subsets which are assumed to be collected from three hospitals.

Flegel's Disease A Very Rare Skin Disease: A Case Report of Mother and Daughter in a Family.

Flegel's disease (FD) or hyperkeratosis lenticularis perstans (HLP) is an extremely exceptional skin disease typified by hyper-keratotic papules usually found on the lower extremities. Only the histopathological study is the confirmatory test for diagnosis this disease. The treatment of Flegel's disease is not yet settled as a standard one.