Publications by authors named "M Rashtian"
Article Synopsis
- A new dual chamber leadless pacemaker system utilizes a temperature-based sensor to monitor heart rate response during exercise, focusing on its effectiveness in both the right ventricle and right atrium.
- An exercise test was conducted 6 weeks post-implant on eligible subjects to evaluate the pacing response of the ventricular and atrial devices, measuring if the rate increased proportionately with metabolic workload.
- Results showed that both the ventricular and atrial devices had mean rate-response slopes (0.93 and 0.91, respectively) within the acceptable range, indicating that the temperature-based sensor effectively adjusts pacing to meet increased metabolic demands.
Background: A dual-chamber leadless pacemaker system has been designed for atrioventricular synchronous pacing using wireless, beat-to-beat, implant-to-implant (i2i) communication between distinct atrial and ventricular leadless pacemakers. The atrioventricular synchrony achieved across various ambulatory scenarios has yet to be systematically evaluated.
Methods: A prospective, single-arm, unblinded, multicenter, international clinical trial of the leadless pacemaker system was conducted in patients with a conventional dual-chamber pacing indication enrolled from February 2022 to March 2023.
Retrieval of Chronically Implanted Dual-chamber Leadless Pacemakers in an Ovine Model.
Circ Arrhythm Electrophysiol
October 2023
Background: The clinical utilization of leadless pacemakers (LPs) as an alternative to traditional transvenous pacemakers is likely to increase with the advent of dual-chamber LP systems. Since device retrieval to allow LP upgrade or replacement will become an important capability, the first such dual-chamber, helix-fixation LP system (Aveir DR; Abbott, Abbott Park, IL) was specifically designed to allow catheter-based retrieval. In this study, the preclinical performance and safety of retrieving chronically implanted dual-chamber LPs was evaluated.
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- A dual-chamber leadless pacemaker system, involving devices placed in both the right atrium and right ventricle, aims to improve treatment options for patients needing pacemakers without the conventional wiring.
- In a study of 300 patients, the new system demonstrated high safety, with 90.3% of participants avoiding serious complications within 90 days, which surpassed the target benchmark.
- The effectiveness of the pacemaker was also confirmed, as 90.2% of patients achieved satisfactory atrial capture and sensing performance, indicating it can reliably support necessary heart functions.
Background: Dual-chamber leadless pacemakers (LPs) require robust communication between distinct right atrial (RA) and right ventricular (RV) LPs to achieve atrioventricular (AV) synchrony.
Objective: The purpose of this preclinical study was to evaluate a novel, continuous implant-to-implant (i2i™) communication methodology for maintaining AV-synchronous, dual-chamber DDD(R) pacing by the 2 LPs.
Methods: RA and RV LPs were implanted and paired in 7 ovine subjects (4 with induced complete heart block).