Curcumin-Etoposide Synergy: Unveiling the Molecular Mechanisms of Enhanced Apoptosis and Chemoresistance Attenuation in Breast Cancer.

Background: Combining natural compounds with chemotherapeutic agents has emerged as a promising approach for cancer treatment. Curcumin (Cur), a natural polyphenol, is known for its anti-cancer properties, including the ability to induce apoptosis and arrest cell cycle progression.

Objectives: This study aimed to evaluate the effects of Cur and etoposide (ETO), both individually and in combination, on the induction of apoptosis in breast cancer (BC) cell lines.

Determination of the relationship between frailty level and quality of life in elderly individuals with type 2 diabetes.

The aim of the study was to examine the relationship between frailty level and quality of life in elderly individuals with Type 2 diabetes. This descriptive and correlational study was conducted with 211 patients who applied to the diabetes outpatient clinic of a private and a public hospital in Istanbul between September and November 2022. The data were obtained by using the Personal Information Form, Edmonton Frail Scale and the Quality of Life in the Elderly Scale.

Recent advances in potential enzymes and their therapeutic inhibitors for the treatment of Alzheimer's disease.

Alzheimer's disease (AD), a chronic neurodegenerative disease, is clinically characterized by loss of memory and learning ability among other neurological deficits. Amyloid plaques, hyperphosphorylated tau protein, and neurofibrillary tangles involve in AD etiology. Meanwhile, enzymes and their inhibitors have become the focus of research in AD treatment.

A decision rule algorithm for the detection of patients with hypertension using claims data.

Objectives: Claims data covers a large population and can be utilized for various epidemiological and economic purposes. However, the diagnosis of prescriptions is not determined in the claims data of many countries. This study aimed to develop a decision rule algorithm using prescriptions to detect patients with hypertension in claims data.

Combining anti-checkpoint immunotherapies and cancer vaccines as a novel strategy in oncological therapy: A review.

The field of cancer immunotherapy has experienced remarkable advancements in the treatment of human cancers over recent decades. Therapeutic cancer vaccines have been employed to elicit antitumor immune responses through the generation of specific reactions against tumor-associated antigens. Although preclinical studies have demonstrated hopeful results and at least one product is approved for clinical use, the overall efficacy of cancer vaccines remains restricted.