Publications by authors named "M Rappolt"

Lipid nanoparticles have important applications as biomedical delivery platforms and broader engineering biology applications in artificial cell technologies. These emerging technologies often require changes in the shape and topology of biological or biomimetic membranes. Here we show that topologically-active lyotropic liquid crystal nanoparticles (LCNPs) can trigger such transformations in the membranes of giant unilamellar vesicles (GUVs).

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Article Synopsis
  • Periodontal disease is caused by bacterial biofilms that resist typical antibiotic treatments, prompting research into alternative delivery methods for antimicrobial peptides.
  • The study focused on the cationic antimicrobial peptide LL17-32, a 16-amino acid fragment of LL-37, and its effectiveness against a key periodontal pathogen using liposome-based delivery systems.
  • Results showed that liposomal formulations with high molecular weight chitosan improved stability and association with LL17-32, but the peptide’s microbicidal activity was reduced when delivered via liposomes compared to when used alone.
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Cocoa butter equivalents (CBE) are mixtures of triglycerides from multiple sources (e.g., sunflower oil, mango kernel and sal), which resemble cocoa butter (CB) in both physical and chemical properties.

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Packing stress in the lipidic inverse hexagonal H phase arises from the necessity of the ideally cylinder-shaped micelles to fill out the hexagonally-shaped Wigner-Seitz unit cell. Thus, hydrocarbon chains stretch towards the corners and compress in the direction of the flat side of the hexagonal unit cell. Additionally, the lipid/water interface deviates from being perfectly circular.

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Correction for 'Planar confined water organisation in lipid bilayer stacks of phosphatidylcholine and phosphatidylethanolamine' by Gerome Vancuylenberg , , 2023, https://doi.org/10.1039/D3SM00387F.

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