Publications by authors named "M Ramundo"
Article Synopsis
- Chikungunya virus (CHIKV) can lead to severe diseases, including chronic arthritis and, in rare cases, neurological issues and death, primarily transmitted by mosquitoes.
- A comprehensive study revealed that deaths from CHIKV are linked to multi-organ infections, serious brain damage, and higher levels of inflammation in the body compared to survivors.
- The research also found that CHIKV infection disrupts the blood-brain barrier, leading to increased permeability and changes in protein expression, enhancing our understanding of CHIK pathophysiology and fatal outcomes.
Article Synopsis
- The study discusses the immune responses of an HIV-infected patient suffering from mucosal leishmaniasis, a condition not well understood in terms of immune reactions.
- The patient had a notably low CD4 count of 85 cells/mm3 and experienced significant nasal damage over 2 years due to the disease.
- Immune evaluations indicated a mixed Th1/Th2 response alongside both activated and exhausted T cells, enhancing our understanding of HIV's impact on responses to mucosal leishmaniasis.
Article Synopsis
- The study assessed the effectiveness and safety of durvalumab combined with gemcitabine and cisplatin in patients with advanced biliary tract cancer, following promising results from the TOPAZ-1 trial.
- A total of 145 patients participated, with a median progression-free survival of 8.9 months and overall survival of 12.9 months, showing a 34.5% response rate to treatment.
- Adverse events were common, with 94.5% experiencing some degree of side effect, but the serious immune-related side effects were relatively low at 2.1%, indicating that the treatment is generally manageable in a real-world setting.
Chikungunya (CHIK) is a debilitating mosquito-borne disease with an epidemiology and early clinical symptoms similar to those of other arboviruses-triggered diseases such as dengue or Zika. Accurate and rapid diagnosis of CHIK virus (CHIKV) infection is therefore challenging. This international study evaluated the performance of the automated VIDAS anti-CHIKV IgM and IgG assays compared to that of manual competitor IgM and IgG ELISA for the detection of anti-CHIKV IgM and IgG antibodies in 660 patients with suspected CHIKV infection.
View Article and Find Full Text PDFEmerging and re-emerging viruses are a global health concern. Genome sequencing as an approach for monitoring circulating viruses is currently hampered by complex and expensive methods. Untargeted, metagenomic nanopore sequencing can provide genomic information to identify pathogens, prepare for or even prevent outbreaks.
View Article and Find Full Text PDF