Publications by authors named "M Rambla-Alegre"
Freshwater snails of the genus Pomacea, have been introduced worldwide with well-documented ecological and economic impacts. In rice, a crucial crop for global food security, apple snails have become a major pest. Chemical molluscicides, the most effective method of control, raise concerns due to their ecotoxicity.
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- Pufferfish, known for being highly toxic due to neurotoxins like tetrodotoxins and paralytic shellfish toxins, poses a serious risk to human health and has caused many poisoning incidents.
- A study analyzed tissue extracts from two pufferfish species collected from the Spanish Mediterranean, revealing no toxicity in Sphoeroides pachygaster but significant toxicity in the liver of Lagocephalus lagocephalus specimens.
- High-performance liquid chromatography analysis confirmed the presence of paralytic shellfish toxins, particularly saxitoxin and decarbamoylsaxitoxin, in L. lagocephalus, highlighting a food safety concern due to the potential risks associated with consuming this toxic fish in the region. *
Article Synopsis
- Tetrodotoxin (TTX) is a dangerous marine neurotoxin linked to various poisoning cases and fatalities, with over 30 known analogues, but their toxic effects are not fully understood.
- This study focused on determining the toxicity equivalency factors (TEFs) of five TTX analogues by examining how they affect voltage-gated sodium channels in Neuro-2a cells using an automated patch clamp method.
- Results showed that all TTX analogues were less toxic than TTX, and the derived TEFs can effectively convert LC-MS/MS data from pufferfish samples into relevant toxicological insights, emphasizing the potential of this method for food safety and health protection.
Spirolides (SPXs), gymnodimines (GYMs), and pinnatoxins (PnTXs) have been detected in shellfish from the northwestern Mediterranean coast of Spain. Several samples of bivalves were collected from Fangar Bay and Alfacs Bay in Catalonia over a period of over 7 years (from 2015 to 2021). Shellfish samples were analyzed for cyclic imines (CIs) on an LC1200 Agilent and 3200 QTrap triple-quadrupole mass spectrometer.
View Article and Find Full Text PDFTetrodotoxin (TTX) is a potent marine neurotoxin involved in poisoning cases, especially through the consumption of puffer fish. Knowledge of the toxicity equivalency factors (TEFs) of TTX analogues is crucial in monitoring programs to estimate the toxicity of samples analyzed with instrumental analysis methods. In this work, TTX analogues were isolated from the liver of a individual caught on South Crete coasts.
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