Publications by authors named "M Ramakers"
EuroGuiderm guideline on lichen sclerosus-Treatment of lichen sclerosus.
J Eur Acad Dermatol Venereol
October 2024
Article Synopsis
- Lichen sclerosus (LS) is a skin condition primarily affecting the anogenital area, causing symptoms like itching, soreness, and potential sexual and urinary dysfunction, with a risk of genital cancer and significant impacts on quality of life.
- The guideline aims to improve the diagnosis and treatment of LS, offering evidence-based recommendations for different therapies and care approaches, especially during pregnancy and follow-up.
- Topical corticosteroids are the primary treatment for LS in both sexes, with surgery as an option for males if standard treatments fail, while UV light therapy is suggested for non-genital LS, despite limited research.
EuroGuiderm guideline on lichen sclerosus-introduction into lichen sclerosus.
J Eur Acad Dermatol Venereol
October 2024
Article Synopsis
- Lichen sclerosus (LS) is an inflammatory skin condition primarily affecting the anogenital area, leading to symptoms like itching, soreness, and potentially serious complications such as urinary and sexual dysfunction, along with an increased risk of genital cancer.
- *The guideline aims to provide a comprehensive approach for diagnosing and treating LS, including recommendations for topical and surgical treatments, as well as care considerations for patients during pregnancy and ongoing management.
- *Topical corticosteroids are considered the standard treatment for LS, with additional options like emollients and, if ineffective, surgical interventions such as circumcision for males; UV light therapy is also suggested for non-genital forms of LS despite limited evidence.
Tauopathies encompass a group of neurodegenerative disorders characterised by diverse tau amyloid fibril structures. The persistence of polymorphism across tauopathies suggests that distinct pathological conditions dictate the adopted polymorph for each disease. However, the extent to which intrinsic structural tendencies of tau amyloid cores contribute to fibril polymorphism remains uncertain.
View Article and Find Full Text PDFThere is an arms race between beta-lactam antibiotics development and co-evolving beta-lactamases, which provide resistance by breaking down beta-lactam rings. We have observed that certain beta-lactamases tend to aggregate, which persists throughout their evolution under the selective pressure of antibiotics on their active sites. Interestingly, we find that existing beta-lactamase active site inhibitors can act as molecular chaperones, promoting the proper folding of these resistance factors.
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