Publications by authors named "M Rajkhowa"
Article Synopsis
- Some women trying to get pregnant with embryo transfers have a hard time, known as recurrent implantation failure (RIF), and doctors are looking for ways to help them.
- This study looked at whether a special type of medicine, called immunomodulators, could increase the chances of having a baby for women with RIF who were undergoing treatment.
- The results showed that women who took immunomodulators had a better chance of having a baby compared to those who only received standard treatment, with a live birth rate of 20.9% versus 15.8%.
Study Question: What is the association between serum progesterone levels on the day of frozen embryo transfer (FET) and the probability of live birth in women undergoing different FET regimens?
Summary Answer: Overall, serum progesterone levels <7.8 ng/ml were associated with reduced odds of live birth, although the association between serum progesterone levels and the probability of live birth appeared to vary according to the route of progesterone administration.
What Is Known Already: Progesterone is essential for pregnancy success.
Article Synopsis
- This study investigates the link between serum progesterone levels and the success of frozen embryo transfers (FET) in women trying to conceive.
- By reviewing existing research, it finds that higher progesterone levels (below 10 ng/mL) significantly improve ongoing pregnancy rates and reduce miscarriage risks, particularly when using vaginal progesterone and blastocyst embryos.
- The authors suggest that a certain level of progesterone is crucial for embryo implantation, and they recommend more clinical trials to see if higher doses of progesterone can enhance FET outcomes for women with low levels.
Study Question: What is the clinical-effectiveness and safety of the endometrial scratch (ES) procedure compared to no ES, prior to usual first time in vitro fertilisation (IVF) treatment?
Summary Answer: ES was safe but did not improve pregnancy outcomes when performed in the mid-luteal phase prior to the first IVF cycle, with or without intracytoplasmic sperm injection (ICSI).
What Is Known Already: ES is an 'add-on' treatment that is available to women undergoing a first cycle of IVF, with or without ICSI, despite a lack of evidence to support its use.
Study Design, Size, Duration: This pragmatic, superiority, open-label, multi-centre, parallel-group randomised controlled trial involving 1048 women assessed the clinical effectiveness and safety of the ES procedure prior to first time IVF, with or without ICSI, between July 2016 and October 2019.
Background: Vitamin D deficiency has been associated with an increased risk of abnormal pregnancy implantation leading to obstetric complications such as pre-eclampsia and fetal growth restriction. However, the effect of vitamin D on reproductive treatment outcomes in couples undergoing assisted reproductive treatment is poorly understood. This study investigates the association between vitamin D and reproductive treatment outcomes in women undergoing assisted reproductive treatments?
Methods: A prospective cohort study conducted at a large tertiary teaching hospital, United Kingdom.