A novel breath pattern model and analysis to minimize patient discomfort in medical ventilators.

Typical waveforms used for the simulation of pressure and volume-controlled ventilation in medical ventilators have been extensively studied in the literature. The majority of simulation studies reported employ the step pattern or ramp pattern to model the pressure and flow variations in pressure/volume-controlled ventilation. It was observed that the above waveforms tend to add to the discomfort level of patients due to the presence of jerks in derivatives of pressure/flow variations; the pressure/flow variation of air and oxygen mixture should be smooth so that the patient discomfort is kept at a minimal level.

ICMR-MDRF Diabetes Biosamples: Cohort profile.

Background & objectives Biobanks are crucial for biomedical research, enabling new treatments and medical advancements. The biobank at the Madras Diabetes Research Foundation (MDRF) aims to gather, process, store, and distribute biospecimens to assist scientific studies. Methods This article details the profile of two cohorts: the Indian Council of Medical Research-India Diabetes (ICMR-INDIAB) study and the Registry of people with diabetes in India with young age at onset (ICMR-YDR).

SrZrCu ( = S and Se): two novel layered quaternary mixed transition metal chalcogenides.

Depending on their bandgaps, mixed metal layered chalcogenides are potential candidates for thermoelectric and photovoltaic applications. Herein, we reported the exploratory synthesis of Sr-Zr-Cu- ( = S/Se) systems, resulting in the identification of two novel quaternary chalcogenides: SrZrCuS and SrZrCuSe. These isoelectronic compounds (SrZrCu) crystallized in two different structural types.

In-situ synthesis and evaluation of anti-bacterial efficacy and angiogenesis of curcumin encapsulated lipogel dermal patch for wound healing applications.

The development of synthetic hydrogels as a dermal patch offers unique advantage of providing moist environment around the wound site. The incorporation of curcumin in hydrogel plays a significant role in the healing process of chronic wounds. The present investigation aims to develop nano-formulated curcumin-fused lipogel to impart the dual advantages of sustained drug release and enhanced wound healing ability.

Early pregnancy HbA as the first screening test for gestational diabetes: results from three prospective cohorts.

Background: More than 90% of gestational diabetes cases are estimated to occur in low-income and middle-income countries (LMICs). Most current guidelines recommend an oral glucose tolerance test (OGTT) at 24-28 weeks of gestation. The OGTT is burdensome, especially in LMICs, resulting in a high proportion of women not being screened.