Do socioeconomic factors impair uptake of neoadjuvant therapy for patients with locoregional oesophageal cancer?

Objectives: The benefits of neoadjuvant therapy prior to surgery for patients with locally advanced oesophageal cancer have been well established by multiple trials. However, there may be socioeconomic barriers impacting equitable administration. We aim to identify whether disparities exist in uptake of neoadjuvant therapy among patients with loco-regional oesophageal cancer.

Synthesis, optical linear and non-linear characterization and metal ion sensing application of some novel thieno[2,3-b]thiophene-2,5-dicarbohydrazide Schiff base derivatives.

Synthesized 3,4-Diaminothieno[2,3-b]thiophene-2,5-dicarbohydrazide (DTT) Schiff base derivatives newly were synthesized by attaching with different aldehydes, deposited in thin film form by thermal evaporation technique, and characterized by UV-Visible-NIR spectroscopy, FT-IR, NMR, and elemental analysis. It is revealed that compound 4 has the highest absorption peak intensity at 586 nm. The allied absorption, dielectric, and dispersion parameters have been calculated and discussed.

Effect of early follicular phase of menstrual cycle on hip flexion-extension isokinetic parameters in sedentary female students.

Researchers conducted this observational study on sixty young females to detect the effect of the early follicular phase of the menstrual cycle on hip muscle performance. The Biodex Isokinetic dynamometer 4 pro was used. The authors used a dependent t-test and detected a statistically significant increase in the mean values of all hip flexion and extension isokinetic parameters at angular velocities 90°/sec and 180°/sec ( < 0.

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel Film.

A new fusidic acid-loaded hydrogel film was prepared via the solvent casting technique using alginate and Aloe vera. The hydrogel films were optimized using different ratios of sodium alginate, Aloe vera, and glycerin. The films containing 10% glycerin (w/w of alginate) exhibited the best appearance.

Surgery for Patients With cT3/4N2M0, Stage IIIB NSCLC. Is It Time to Redefine Resectability?

Introduction: Chemoradiation followed by durvalumab is considered a standard approach for patients with locally advanced NSCLC. With improvements in perioperative and neoadjuvant approaches, there is renewed interest in offering surgery to carefully selected patients with cT3/4N2 stage IIIB cancer. We sought to assess survival outcomes after surgery as part of a multimodality treatment regimen for these patients.