Publications by authors named "M Raftery"
Objectives: The EyeGuide Focus system is a simple, portable, test of visual tracking with potential use for concussion screening. This study investigated the repeatability, reproducibility, distribution, and modifiers of EyeGuide Focus measurements in healthy elite Rugby players.
Design: Cross sectional repeated measures study and controlled pre-test post-test sub-study.
Article Synopsis
- Hypomethylating agents (HMAs) are key treatments for Myelodysplastic Neoplasms (MDS) and Acute Myeloid Leukemia (AML), but patients often develop resistance and experience treatment failure.
- Researchers conducted a genome-wide CRISPR-Cas9 screen in MDS-derived cells, discovering that targeting the gene TOPORS enhances the effectiveness of HMAs by making cancer cells more vulnerable to DNA damage.
- The study suggests that combining HMAs with strategies to inhibit SUMOylation or TOPORS could be an effective treatment approach for patients with high-risk MDS or AML, without harming normal blood cell production.
Article Synopsis
- * Scientists studied the RSX interactome and found 135 proteins linked to it, with 54 of those being similar to proteins connected to XIST.
- * Both RSX and XIST are involved in similar processes that help control how genes are used in cells, showing that even different animals can have similar genetic functions that evolved separately.
Background: Beta-(1,3)(1,6)-D-glucan is a complex polysaccharide, which is found in the cell wall of various fungi, yeasts, bacteria, algae, barley, and oats and has immunomodulatory, anticancer and antiviral effects. In the present study, we investigated the effect of beta-(1,3)(1,6)-D-glucan derived from yeast on the proliferation of primary NK cells and breast cancer cell lines in 2D and 3D models, and on the cytotoxicity of primary NK cells against breast cancer cell lines in 2D and 3D models.
Methods: In this study, we investigated the effects of different concentrations of yeast-derived beta-(1→3)(1→6)-D-glucan on the proliferation and cytotoxicity of human NK cells and breast cancer cell lines in 2D and 3D models using the XTT cell proliferation assay and the CellTiter-Glo® 2.
Colorectal carcinoma (CRC) presents a formidable medical challenge, demanding innovative therapeutic strategies. Chimeric antigen receptor (CAR) natural killer (NK) cell therapy has emerged as a promising alternative to CAR T-cell therapy for cancer. A suitable tumor antigen target on CRC is carcinoembryonic antigen (CEA), given its widespread expression and role in tumorigenesis and metastasis.
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