Publications by authors named "M Rafiee"
Article Synopsis
- Acute myeloid leukemia (AML) is the most common and deadliest acute leukemia in adults, especially impacting those over 65 who have a low survival rate of 30% within a year.
- There is a critical need to improve treatment outcomes as many patients struggle to predict responses to therapies and frequently relapse.
- The review highlights recent advancements in omics technologies that can enhance the understanding of AML's biological mechanisms, offering insights for better diagnosis, prognosis, and potential new therapies.
Climate change significantly impacts the risk of eutrophication and, consequently, chlorophyll-a (Chl-a) concentrations. Understanding the impact of water flows is a crucial first step in developing insights into future patterns of change and associated risks. In this study, the Statistical DownScaling Model (SDSM)-a widely used daily downscaling method-is implemented to produce downscaled local climate variables, which serve as input for simulating future hydro-climate conditions using a hydrological model.
View Article and Find Full Text PDFNickel-catalyzed cross-electrophile coupling (XEC) reactions of (hetero)aryl electrophiles represent appealing alternatives to palladium-catalyzed methods for biaryl synthesis, but they often generate significant quantities of homocoupling and/or proto-dehalogenation side products. In this study, an informer library of heteroaryl chloride and aryl bromide coupling partners is used to identify Ni-catalyzed XEC conditions that access high selectivity for the cross-product when using equimolar quantities of the two substrates. Two different catalyst systems are identified that show complementary scope and broad functional-group tolerance, and time-course data suggest that the two methods follow different mechanisms.
View Article and Find Full Text PDFArticle Synopsis
- - The study focuses on the incidence and impact of five common cancers (skin, breast, gastric, colorectal, and lung) in the elderly, using data from Markazi province's cancer registry in 2019.
- - Data was collected from residents older than 60, examining cancer incidence, death rates, survival, and disability, utilizing tools like Excel and DISMOD2 to analyze the burden of diseases through the Disability-Adjusted Life Years (DALY) metric.
- - Results showed varying incidence rates and DALYs between elderly men and women, with gastric cancer having the highest impact in terms of years of life lost (YLL) and years lived with disability (YLD).
Article Synopsis
- * A new thin-layer electrode (TLE) enables flexible experimental designs to observe reaction mechanisms of drug metabolites in a time-sensitive manner, which is crucial for accurate analysis.
- * The TLE, when used with a microelectrode, allows detailed study of drug metabolic oxidation, exemplified by the oxidation of acetaminophen and related drugs, facilitating structural analysis of reaction intermediates and products.