Publications by authors named "M Radin"
Background/objectives: Inflammation and immunological dysregulation are central to systemic lupus erythematosus (SLE), a complex autoimmune disease. Recently, there has been increasing interest in the potential role of dietary factors in SLE. This study aimed to explore the relationship between diet and SLE by addressing patient needs, conducting a systematic review, and providing guidance to the patient community.
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- - A treat-to-target (T2T) approach focuses on setting specific therapeutic goals for disease management, requiring regular check-ins and treatment adjustments to improve patient outcomes.
- - Implementing T2T in Antiphospholipid Syndrome (APS) is challenging due to the disease's diverse symptoms and the absence of reliable markers to measure disease activity.
- - Despite these difficulties, T2T strategies remain crucial for APS management, aiming to control the disease better, minimize recurrence risks, and improve patients' overall quality of life.
How to treat patients with thrombotic antiphospholipid syndrome in 2024?
Pol Arch Intern Med
November 2024
Antiphospholipid syndrome (APS) encompasses a range of clinical conditions, particularly thrombotic or obstetrical manifestations, associated with the presence of antiphospholipid antibodies. Managing thrombotic APS in daily clinical practice can be challenging and requires thorough risk stratification and tailored treatment strategies. Primary prophylaxis focuses on correcting the traditional thrombotic risk factors and, in certain situations, may include low‑dose aspirin and / or prophylactic anticoagulants (eg, low‑molecular‑weight heparin).
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- - This study examined the occurrence and effects of antinuclear antibodies (ANA) in patients with antiphospholipid antibodies (aPL) but without other systemic autoimmune diseases, using data from the APS ACTION Registry.
- - Among the 430 analyzed patients, 56% tested positive for ANA, revealing significant links between ANA positivity and various autoimmune features like hematologic issues and joint involvement.
- - Despite the presence of these autoimmune characteristics in ANA-positive patients, the study found no connection between ANA status and complications related to thrombosis or pregnancy; interestingly, ANA-negative patients had more pregnancies and live births.