Publications by authors named "M ROSENBAUM"
Objective: We examined whether riluzole treatment modifies the associations between the dietary glycemic index (GI) and load (GL) and disease progression in amyotrophic lateral sclerosis (ALS).
Methods: Sporadic ALS patients in the Multicenter Cohort Study of Oxidative Stress who completed a baseline food frequency questionnaire were included (n = 304). Interactions between baseline riluzole treatment and GI/GL on functional decline and tracheostomy-free survival were examined using linear regression and Cox proportional hazard models adjusted for covariates.
Article Synopsis
- The study aimed to evaluate the feasibility and patient satisfaction of telegenetic counseling (tele-GC) versus traditional in-person genetic counseling (in-person GC) for Huntington disease (HD) genetic testing, addressing accessibility issues faced by patients due to geography or cost.
- Results showed high satisfaction levels for both counseling methods, with median satisfaction scores of 10/10, but most symptomatic HD participants preferred in-person counseling, despite tele-GC's advantage in reducing travel time.
- Participants reported that visual interaction with genetic counselors helped with understanding and emotional engagement, although some technical difficulties arose during tele-GC sessions.
Fungal infections pose a great threat to public health and there are only four main types of antifungal drugs, which are often limited with toxicity, drug-drug interactions and antibiotic resistance. Streptomyces is an important source of antibiotics, represented by the clinical drug amphotericin B. Here we report the discovery of alligamycin A (1) as an antifungal compound from the rapamycin-producer Streptomyces iranensis through genome-mining, genetics and natural product chemistry approaches.
View Article and Find Full Text PDFDespite the increasing inclusion of communication skills in accreditation standards and an increase in time dedicated to teaching these skills, communication is often regarded as a separate skill and is therefore, not consistently represented in overall systems of assessment in Health Professions Education (HPE). The ascendence of competency-based medical education, programmatic assessment, artificial intelligence, and widespread use of telehealth, alongside changing patient expectations warrant an update in thinking about the assessment of communication skills in health professions education. This consensus statement draws on existing literature, expert pinion, and emerging challenges to situate the assessment of communication skills in the contemporary health professions education context.
View Article and Find Full Text PDFLongitudinal changes in systemic right ventricular remodeling in adult patients with transposition of the great vessels as assessed by cardiovascular magnetic resonance imaging.
J Cardiovasc Magn Reson
December 2024
Background: Systemic right ventricular (sRV) physiology occurs in patients with congenitally corrected transposition of the great arteries (ccTGA) and D-TGA post atrial switch repair, and the natural history is of progressive sRV dysfunction. No study has assessed longitudinal changes in sRV remodeling by serial cardiovascular magnetic resonance (CMR).
Methods: Patients evaluated at two adult congenital heart disease centers and who underwent ≥2 CMR exams were studied.