Publications by authors named "M R Yeaman"
Background: We evaluated comprehension and application of the 2015 neuromyelitis optica spectrum disorder (NMOSD) criteria core elements by neurologists in Latin America (LATAM) who routinely diagnose and care for NMOSD patients by (i) identifying typical/suggestive NMOSD syndromes, (ii) detecting typical MRI NMOSD lesions and meeting MRI dissemination in space (DIS) criteria, and (iii) evaluating historical symptoms suggestive of NMOSD.
Methods: We conducted an anonymous, voluntary, self-administered web- and case-based survey cross-sectional study from October 2023 to January 2024 of neurologists identified through the LACTRIMS database. Questions were presented first through iterative clinical cases or imaging, followed by questions directly evaluating comprehension of definitions.
Article Synopsis
- Patients with neuromyelitis optica spectrum disorder (NMOSD) often have antibodies against aquaporin-4 (AQP4), making MRI monitoring critical for understanding the disease's progression.
- A retrospective study involved MRI data from 525 AQP4-IgG-seropositive NMOSD patients across 11 countries, focusing on the types and locations of lesions in the central nervous system.
- Results showed a high prevalence of hyperintense lesions in the brain and significant patterns of myelitis in the spinal cord, emphasizing the importance of MRI in tracking this condition.
Article Synopsis
- * The analysis was done on a group of 505 patients, with a detailed subset of 198, all from a database of individuals with NMOSD in North America to identify factors affecting disability over time.
- * Key findings revealed that prior relapses were linked to worse mobility, vision, and self-care, with additional insights showing that certain demographics, like race and disease subtype, impacted disability, highlighting the need for specialized assessments for NMOSD to better manage and understand
Article Synopsis
- Candidalysin, produced by Candida albicans, is a virulence factor that damages host cells, and this study identified specific genes related to glycosaminoglycan (GAG) biosynthesis that, when disrupted, confer resistance to this damage.
- Researchers found that candidalysin binds to sulfated GAGs on the host cell surface, which helps it to cause damage, but adding exogenous sulfated GAGs like dextran sulfate can protect cells and inhibit candidalysin's effects.
- In a mouse model of vulvovaginal candidiasis, applying dextran sulfate reduced tissue damage and inflammation, suggesting sulfated GAGs are potential therapeutic targets to counteract candidalysin-related damage.
Human lactoferrin (hLf) is an innate host defense protein that inhibits microbial H-ATPases. This protein includes an ancestral structural motif (i.e.
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