Publications by authors named "M R Wilson"
Article Synopsis
- The study examines the experiences of Pacific peoples in Aotearoa New Zealand with cancer treatment, focusing on the disparities they face compared to other ethnic groups.
- Data were collected through interviews with Samoan and Tongan patients, revealing five significant themes: perceptions of cancer, the need for holistic support, importance of communication and trust, financial barriers to care, and the need for better representation in healthcare.
- The findings emphasize the necessity for improved oncology care models that address the unique cultural and systemic challenges faced by Pacific communities to enhance access and support.
Objective: Monoallelic variants in the transient receptor potential melastatin-related type 3 gene (TRPM3) have been associated with neurodevelopmental manifestations, but knowledge on the clinical manifestations and treatment options is limited. We characterized the clinical spectrum, highlighting particularly the epilepsy phenotype, and the effect of treatments.
Methods: We analyzed retrospectively the phenotypes and genotypes of 43 individuals with TRPM3 variants, acquired from GeneMatcher and collaborations (n = 21), and through a systematic literature search (n = 22).
Article Synopsis
- A novel noninvasive method combines magnetic and focused ultrasonic fields to create electric fields deep in the brain for potential treatments of mental and neurological disorders.
- This study tested this method on non-human primates' visual circuits, examining the effects of different ultrasonic pulse frequencies on neural activity.
- Results showed that low-frequency stimulation (5 Hz) inhibited brain activity, while higher frequencies did not, indicating the importance of pulse frequency in neuromodulation without safety concerns.
NMDA receptor mediated autoimmune encephalitis (NMDAR-AE) frequently results in persistent sensory-motor deficits, especially in children, yet the underlying mechanisms remain unclear. This study investigated the long- term effects of exposure to a patient-derived GluN1-specific monoclonal antibody (mAb) during a critical developmental period (from postnatal day 3 to day 12) in mice. We observed long-lasting sensory-motor deficits characteristic of NMDAR-AE, along with permanent changes in callosal axons within the primary somatosensory cortex (S1) in adulthood, including increased terminal branch complexity.
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