Publications by authors named "M R Waltz"
Background: Nonhuman animals are regularly enhanced genomically with CRISPR and other gene editing tools as scientists aim at better models for biomedical research, more tractable agricultural animals, or animals that are otherwise well suited to a defined purpose. This study investigated how genome editors and policymakers perceived ethical or policy benefits and drawbacks for animal enhancement and how perceived benefits and drawbacks are alike, or differ from, those for human genome editing.
Methods: We identified scientists through relevant literature searches as well as conference presentations.
Background And Objectives: Accumulating evidence points to worse clinical outcomes among adults with multiple sclerosis (MS) belonging to minority or poverty-affected groups. By contrast, little is known about the outcomes of these populations with pediatric-onset MS (POMS). Individuals with POMS represent 5% of the MS population and are more racially diverse yet have been understudied regarding socioeconomic environment or characteristics.
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- The study investigates how social determinants of health (SDOH) impact pediatric-onset multiple sclerosis (POMS), particularly in terms of adverse SDOH frequency and their effects on treatment and outcomes.
- Researchers conducted a retrospective analysis of data from the United States Network of Pediatric MS Centers, focusing on various demographic and clinical outcomes related to SDOH hardships.
- Findings indicated that 66% of participants faced social hardships, which influenced factors such as age at symptom onset, steroid treatment likelihood, study attrition risk, and overall health scores.
ADEM is an inflammatory disease, with new onset polyfocal neurologic symptoms, encephalopathy and multifocal demyelination, typically in childhood. Initial diagnosis of ADEM is challenging and up to 20 % of children with MS or NMOSD are initially diagnosed with ADEM. We describe characteristics of patients with monophasic ADEM vs.
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- * The analysis was done on a group of 505 patients, with a detailed subset of 198, all from a database of individuals with NMOSD in North America to identify factors affecting disability over time.
- * Key findings revealed that prior relapses were linked to worse mobility, vision, and self-care, with additional insights showing that certain demographics, like race and disease subtype, impacted disability, highlighting the need for specialized assessments for NMOSD to better manage and understand