Publications by authors named "M R Vissers"
We present a method of creating high-density superconducting flexible wiring on flexible thin silicon substrates. The flexible wiring, called , is created by depositing superconducting wiring on a silicon-on-insulator (SOI) wafer, selectively etching away the thicker silicon section layer, and bending the thinner silicon layer. We show measurements of superconducting transition temperature and critical current for Mo, Nb, and Al on SOI flex.
View Article and Find Full Text PDFSingle-photon detectors based on the superconducting transition-edge sensor are used in a number of visible to near-infrared applications, particularly for photon-number-resolving measurements in quantum information science. To be practical for large-scale spectroscopic imaging or photonic quantum computing applications, the size of visible to near-infrared transition-edge sensor arrays and their associated readouts must be increased from a few pixels to many thousands. In this manuscript, we introduce the kinetic inductance current sensor, a scalable readout technology that exploits the nonlinear kinetic inductance in a superconducting resonator to make sensitive current measurements.
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- Glioblastoma, an aggressive brain cancer, is linked to low oxygen levels (hypoxia) and poor patient survival, driven by the activity of a transcription factor called hypoxia-inducible factor (HIF).
- HIF-hydroxylases, which require vitamin C (ascorbate) to function, are crucial for regulating HIF and the hypoxic pathway; a decrease in these enzymes leads to increased cancer progression.
- The study showed that glioblastoma cells use the sodium-dependent vitamin C transporter-2 (SVCT2) to accumulate ascorbate, and knocking out this transporter significantly reduced ascorbate levels and limited its ability to suppress the hypoxic pathway, suggesting that boosting ascorbate levels could
Investigational therapeutics that target toxic species of α-synuclein (αSyn) aim to slow down or halt disease progression in patients with Parkinson's disease (PD). Here this 44-week, randomized, placebo-controlled, double-blind, single-center phase 1 study investigated safety, tolerability and immunogenicity of UB-312, an active immunotherapeutic targeting pathological αSyn, in patients with PD. The primary outcome measures were adverse event frequency and change in anti-αSyn antibody titers in blood and cerebrospinal fluid (CSF).
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- Young children and older adults are particularly vulnerable to invasive pneumococcal disease (IPD) due to lower levels of protective antibodies against Streptococcus pneumoniae.
- Research measured IgG and IgA antibodies in serum and saliva across different age groups, revealing that younger children have significantly lower antibody levels and avidity compared to adults.
- The findings suggest that repeated exposure to pneumococci through factors like daycare attendance boosts antibody levels, with young children’s low antibody profiles contributing to their susceptibility to IPD and older adults experiencing different influencing factors.