Publications by authors named "M R Torrisi"
Article Synopsis
- * The study presents a case of a 42-year-old woman with HER-2 positive primary ductal adenocarcinoma, detailing her treatment journey, which included surgery, radiotherapy, chemotherapy, and targeted therapy, leading to a favorable outcome.
- * The report highlights the importance of early diagnosis and a multimodal treatment approach for such aggressive tumors, emphasizing the need for documenting individual cases to improve patient management.
Article Synopsis
- - Oropharyngeal cancer (OphC) during pregnancy is rare but may become more common, and delays in treatment can negatively impact survival; current data on radiation therapy's effects on pregnant patients and their children are limited.
- - A case study describes a 39-year-old pregnant woman with advanced OphC who received surgery and radiation therapy, using techniques to minimize fetal radiation exposure, with an estimated dose of about 50 mSv.
- - The patient remained cancer-free after 10 years, and her daughter, born at nearly 34 weeks, is healthy and performing well in school, suggesting that optimizing radiation treatment during pregnancy can protect both mother and child.
Fibroblast growth factor receptor (FGFR) signaling is a key modulator of cellular processes dysregulated in cancer. We recently found that the high expression of the mesenchymal FGFR2c variant in human pancreatic ductal adenocarcinoma (PDAC)-derived cells triggers the PKCε-mediated improvement of EMT and of MCL-1/SRC-dependent cell invasion. Since other membrane proteins can affect the receptor tyrosine kinase signaling, including transient receptor potential channels (TRPs), in this work, we investigated the role of TRPs in the FGFR2c/PKCε oncogenic axis.
View Article and Find Full Text PDFTraumatic brain injury is damage to the brain occurring after birth, often resulting in the deterioration of cognitive, behavioural, and emotional functions. Neuropsychological evaluation can assist clinicians to better assess the patient's clinical condition, reach differential diagnoses, and develop interventional strategies. However, considering the multiple rating scales available, it is not easy to establish which tool is most suitable for the different brain injury conditions.
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