Publications by authors named "M R Tanas"
Soft tissue sarcomas (STSs) are mesenchymal malignant lesions that develop in soft tissues. Despite current treatments, including radiation therapy (RT) and surgery, STSs can be associated with poor patient outcomes and metastatic recurrences. Neoadjuvant radiation therapy (nRT), while effective, is often accompanied by severe postoperative wound healing complications due to damage to the surrounding normal tissues.
View Article and Find Full Text PDFThe extremophile bacterium D. radiodurans boasts a distinctive cell envelope characterized by the regular arrangement of three protein complexes. Among these, the Type II Secretion System (T2SS) stands out as a pivotal structural component.
View Article and Find Full Text PDFArticle Synopsis
- Abl kinases are often seen as promoting cancer, but they can also inhibit tumor cell growth and movement under certain conditions.
- Using RNA interference, researchers studied the impact of Abl kinases on aggressive metastatic prostate cancer to understand their role in tumor progression.
- The findings showed that reducing Abl kinases led to more aggressive cancer traits, with increased cell motility and growth, highlighting the importance of these kinases in suppressing cancer cell activity and spread.
Purpose: Malignant peripheral nerve sheath tumors (MPNST) are lethal, Ras-driven sarcomas that lack effective therapies. We investigated effects of targeting cyclin-dependent kinases 4 and 6 (CDK4/6), MEK, and/or programmed death-ligand 1 (PD-L1) in preclinical MPNST models.
Experimental Design: Patient-matched MPNSTs and precursor lesions were examined by FISH, RNA sequencing, IHC, and Connectivity-Map analyses.
Article Synopsis
- * A case study is presented of a 12-year-old girl who had an initial diagnosis of alveolar RMS in her left maxillary sinus, but later developed a rare skin metastasis on her left temple.
- * The report includes a summary of previous cases and emphasizes the importance of using an immunohistochemistry panel to accurately diagnose this type of tumor.