Publications by authors named "M R Tagliamonte"
Background: Drug-resistant epilepsy (DRE) secondary to hypothalamic hamartoma (HH) often requires surgical resection or stereotactic radiosurgery, which frequently fail to provide satisfactory outcomes and are associated with severe side effects. Magnetic resonance-guided focused ultrasound (MRgFUS) may represent a minimally invasive surgical approach to HH by offering precise thermal ablation of sub-millimetric brain targets while sparing surrounding structures.
Methods: We present the case of a 19-year-old man with HH-associated DRE, who was successfully treated with MRgFUS.
In March 2024, the Pan American Health Organization (PAHO) issued an alert in response to a rapid increase in Oropouche fever cases across South America. Brazil has been particularly affected, reporting a novel reassortant lineage of the Oropouche virus (OROV) and expansion to previously non-endemic areas beyond the Amazon Basin. Utilising phylogeographic approaches, we reveal a multi-scale expansion process with both short and long-distance dispersal events, and diffusion velocities in line with human-mediated jumps.
View Article and Find Full Text PDFImmune checkpoint inhibitors (ICIs) improve outcomes in advanced melanoma, but many patients are refractory or experience relapse. The gut microbiota modulates antitumor responses. However, inconsistent baseline predictors point to heterogeneity in responses and inadequacy of cross-sectional data.
View Article and Find Full Text PDFWe monitored SARS-CoV-2 variants in Haiti from 2020-2023. Despite Haitian COVID-19 travel restrictions and in the setting of a vaccination rate of 2.7%, the timing and lineage evolution of the Haiti epidemic mirrored what was occurring in the rest of the world.
View Article and Find Full Text PDFArticle Synopsis
- The study explored the relationship between SARS-CoV-2 peptides and tumor-associated antigens (TAAs) to find if they could trigger similar immune responses.
- Researchers identified that many SARS-CoV-2 proteins, particularly the Spike protein from the BNT162b2 vaccine, share significant amino acid sequences with TAAs linked to various cancers like breast and melanoma.
- Findings suggest that prior infection or vaccination against COVID-19 could potentially offer immunity against certain cancers, opening avenues for developing new "multi-cancer" vaccines that exploit these viral similarities for therapeutic benefits.