Publications by authors named "M R Sury"
Article Synopsis
- The bioanalytical community traditionally uses blank matrices from preclinical animals for method validation, as required by guidelines, but this practice is increasingly being questioned.
- Despite scientific support for using surrogate matrices instead, regulatory bodies remain hesitant to accept them for most cases, only allowing them for rare situations.
- The European Bioanalysis Forum is advocating for the broader acceptance of surrogate matrices, emphasizing ethical considerations and the need for continued discussions, backed by new experimental data.
Article Synopsis
- The hemojuvelin-hepcidin regulatory axis is crucial for understanding iron metabolism, especially in the context of ischemic stroke (IS).
- A study involving 45 IS patients measured various iron metabolism biomarkers at two points: on admission and 7 days after the stroke.
- Results indicated increased ferritin levels and decreased hepcidin levels after 7 days, with significantly higher soluble hemojuvelin levels in patients with specific stroke types and those treated with thrombolysis.
Background And Aims: In recent years, there has been a growing interest in factor XIII in ischaemic stroke. The study's main aim was to assess the usefulness of factor XIII concentration determination in patients with acute ischaemic stroke (AIS) treated with thrombolysis with recombinant tissue plasminogen activator (t-PA).
Methods: The study was conducted in two groups of 84 patients with AIS: group I-with thrombolytic therapy and group II-without thrombolysis.
Compared with notifiable disease surveillance, claims-based algorithms estimate higher Lyme disease incidence, but their accuracy is unknown. We applied a previously developed Lyme disease algorithm (diagnosis code plus antimicrobial drug prescription dispensing within 30 days) to an administrative claims database in Massachusetts, USA, to identify a Lyme disease cohort during July 2000-June 2019. Clinicians reviewed and adjudicated medical charts from a cohort subset by using national surveillance case definitions.
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- - The study aimed to identify different subpopulations of patients seeking care post-COVID-19 based on their symptoms and resource utilization to improve personalized care and access to specialized services.
- - Researchers analyzed data from 1,285 COVID-19 patients in Boston, uncovering three distinct clusters, with varying demographics and experiences related to ICU admissions and symptom reporting.
- - Findings show that patients differ significantly in how they utilize recovery resources, indicating the need for tailored strategies to address the specific needs of these diverse subpopulations for better recovery outcomes.