Publications by authors named "M R Shokrollahi"

Article Synopsis
  • DNA double-strand breaks (DSBs) can move to the nuclear envelope for repair, influenced by DNA damage response kinases and specific cytoplasmic microtubules.
  • A new structure, called DSB-capturing nuclear envelope tubules (dsbNETs), forms with the help of various cellular components and plays a role in both DNA repair and survival of cells under stress.
  • dsbNETs are also linked to cancer cell behavior and may be hyper-induced by mutations associated with aging, highlighting their significance in genome organization and stability.
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Objective: Diagnostic casts are one of the standard components of orthodontic records. But they have several drawbacks such as the need for physical space for storage and the risk of breaking due to their brittle composition. Today, the digitalization of orthodontic models is a progress in orthodontics.

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Background: The objectives of this study were to analyze the clinical features and laboratory profiles and risk factors associated with critical illness of children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Methods: One hundred and sixty-six coronavirus disease 2019 (COVID-19) Iranian pediatric patients were recruited through a collaborative research network between March and May 2020. Demographics, clinical, laboratory, and radiological results were obtained from patient files.

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Background: Phencyclidine (PCP, I) and its substituted analogs are significant and broadly abused psychotomimetic drugs that affect the central nervous system. They possess many pharmacological properties due to the presence of specific receptors in the brain.

Aims And Objective: Methyl group, despite strong electron-donating and characters of dipole moments, was placed on various positions of phenyl and amine moieties of phencyclidine along with the substitution of benzylamine, piperazine, and aniline derivatives in place of piperidine ring of phencyclidine to create novel compounds of the core with analgesic properties.

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Microtubules are major cytoskeletal components mediating fundamental cellular processes, including cell division. Recent evidence suggests that microtubules also regulate the nucleus during the cell cycle's interphase stage. Deciphering such roles of microtubules should uncover direct crosstalk between the nucleus and cytoplasm, impacting genome function and organismal health.

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