Real-time drug testing of paediatric diffuse midline glioma to support clinical decision making: The Zurich DIPG/DMG centre experience.

Background: Children diagnosed with diffuse midline gliomas (DMG) have an extremely poor overall survival: 9-12 months from diagnosis with currently no curative treatment options. Given DMG molecular heterogeneity, surgical biopsies are needed for molecular profiling and as part of enrolment into molecular-based and precision medicine type clinical interventions. In this study, we describe the results of real time profiling and drug testing at the diffuse intrinsic pontine glioma/DMG Research Centre at University Children's Hospital Zurich.

Effectiveness of telenutrition in a women's weight loss program.

Objective. The objective of this study is to evaluate the effectiveness of telenutrition versus traditional nutritional consultations for female obese patients in need of nutritional treatment. Methods.

Age group, menarche and regularity of menstrual cycles as efficiency predictors in the treatment of overweight.

Objective: To evaluate if there is a relation between age groups, menarche, menstrual cycles and previous pregnancies with the success of weight loss in obese patients at a nutrition clinic.

Methods: A clinical intervention study was conducted among overweight and obese patients who consulted a nutrition clinic in Barranquilla (Colombia) for the purpose of nutritional assessment. They were subject to a personalized weekly follow-up consultation over the course of 16 weeks in which food consumption patterns, anthropometric measures, body image and self-perception were registered.

Adherence to an overweight and obesity treatment: how to motivate a patient?

Objective. To explore anthropometric changes in normal-weight, overweight and obese subjects who did not dropout or fail a weight loss program over the 16 treatment weeks to improve patient motivation and treatment adherence. Methods.