Publications by authors named "M R Rajan"

With rapid technological advancements, videos are captured, stored, and shared in multiple formats, increasing the requirement for summarization techniques to enable shorter viewing durations. Key Frame Extraction (KFE) algorithms are crucial in video summarization, compression, and offline analysis. This study aims to develop an efficient KFE approach for generic videos.

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Introduction / Objectives: While presence of concomitant SLE and frailty has been associated with greater emergency department (ED) use than SLE alone in young/mid-aged adults, whether frailty increases ED use in older adults with SLE remains unknown. In a nationally representative United States administrative claims dataset, we investigated the association of frailty duration with use of ED services in the SLE population compared with individuals without systemic rheumatic disease (SRD).

Method: We identified Medicare beneficiaries ≥ 65 years with SLE and matched them (1:4) by age and gender with non-SRD comparators with osteoarthritis.

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Haze can significantly reduce visibility and contrast of images captured outdoors, necessitating the enhancement of images. This degradation in image quality can adversely affect various applications, including autonomous driving, object detection, and surveillance, where poor visibility may lead to navigation errors and obscure crucial details. Existing dehazing techniques face several challenges: spatial methods tend to be computationally heavy, transform methods often fall short in quality, hybrid methods can be intricate and demanding, and deep learning methods require extensive datasets and computational power.

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Aim: To validate the diagnostic performance of a custom 96-micro-organism TaqMan PCR card (iCAM) for microbial keratitis (MK) from a single corneal epithelial sample.

Methods: Patients over the age of 18 referred to Cambridge University Hospital with MK were recruited in this single-site prospective cohort study between September 2021 and January 2023. An ocular-specific, customised microarray card (iCAM) was constructed according to primer and probe nucleotide sequences developed in our department to detect bacteria, viruses, and fungi commonly implicated in MK using a single corneal epithelial sample.

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Article Synopsis
  • Phosphatidylinositol 3-kinases (PI3K) are lipid kinases involved in critical cellular processes, and their role in cancer and inflammatory disorders makes them key targets for drug development.
  • The study involves analyzing the crystal structure of human PI3Kγ, simulating interactions with stilbenoid compounds like piceatannol and resveratrol, and designing modified derivatives to enhance their effectiveness.
  • Findings indicate that these compounds bind to the ATP binding site of PI3Kγ, with structural modifications leading to stronger interactions that could result in the development of more potent inhibitors for this enzyme.
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