Publications by authors named "M R Pellico"
Long-term outcome of autologous haematopoietic stem cell transplantation in patients with systemic sclerosis: a comparison with patients treated with rituximab and with traditional immunosuppressive agents.
Arthritis Res Ther
October 2024
Background: Autologous haematopoietic stem cell transplantation (AHSCT) is more effective than conventional immunosuppressive therapies (CIT) in improving the outcome of patients with rapidly progressive diffuse cutaneous systemic sclerosis (dcSSc). So far, there is still a paucity of data comparing AHSCT with rituximab (RTX). Aim of the study is to retrospectively compare, in patients with dcSSc, the effectiveness of AHSCT with that of RTX and CIT.
View Article and Find Full Text PDFThe impact of multimorbidity on QoL in inflammatory myopathies: COVAD cluster analysis.
Rheumatology (Oxford)
September 2024
Article Synopsis
- The study investigates how comorbidities impact the quality of life in patients with idiopathic inflammatory myopathies (IIMs) compared to other autoimmune diseases and healthy individuals, utilizing self-reported data from the COVAD-2 survey.
- Results show IIM patients have significantly higher rates of comorbidities, basic multitasking, complex multitasking, and mental health disorders.
- The presence of these conditions correlates with lower overall physical and mental health scores, suggesting the need for targeted management strategies for IIM patients based on identified clinical clusters.
Article Synopsis
- Lung transplantation (LuTx) is a crucial treatment for patients with systemic sclerosis (SSc) and severe lung disease, aiming to improve survival and overall health outcomes.
- A study of 13 SSc patients who underwent LuTx showed significant improvements in lung function, skin involvement, and overall disease activity over a two-year period.
- The survival rate at two years post-transplant was 92.3%, indicating LuTx is a promising option for SSc patients in advanced stages of the disease, with no unexpected adverse events reported.
Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is a recently characterized disease associated with somatic mutations in the UBA1 gene, which cause dysregulation of ubiquitin-mediated processes. This case describes a 71-year-old male patient with VEXAS syndrome who presented with refractory lung inflammation with a pattern similar to computed tomography hypersensitivity pneumonitis, a novel finding in VEXAS syndrome. The presented clinical case highlights the protean involvement of the lung in VEXAS syndrome and emphasizes the importance of considering interstitial lung disease in the differential diagnosis.
View Article and Find Full Text PDFObjectives: This study aims to evaluate the efficacy and safety of JAK inhibitors (JAKi) in a monocentric cohort of adult patients with juvenile idiopathic arthritis (JIA).
Methods: Patients attending a rheumatology transition clinic were retrospectively included in case of: i) JIA diagnosis according to current classification criteria (1); ii) age ≥18 years and iii) treatment with JAKi for at least 3 months.
Results: Seventeen adult patients with JIA were treated with JAKi (as first JAKi, 9 patients (52.