Publications by authors named "M R P van den Broek"
Medullary thyroid cancer (MTC) is a rare cancer with variable disease course. To enable optimal care, centralization and consensus guidelines are essential. This study describes trends in the incidence, organization of care, surgical treatment, and outcomes of MTC over 30 years in the Netherlands.
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- The study investigates how the yeast C. jadinii grows on ethanol as a carbon source, looking specifically at growth rates, energy requirements, and biomass composition across different culture methods.
- In ethanol-limited conditions, C. jadinii CBS 621 achieves effective biomass yields and demonstrates a stable protein content, even at low growth rates, indicating its potential for producing single-cell protein.
- The research also finds that various C. jadinii strains grow rapidly on ethanol, and the results from chemostat cultures can help model production outcomes in larger fed-batch systems, highlighting differences in protein content due to cultivation conditions.
Tidal marshes are threatened coastal ecosystems known for their capacity to store large amounts of carbon in their water-logged soils. Accurate quantification and mapping of global tidal marshes soil organic carbon (SOC) stocks is of considerable value to conservation efforts. Here, we used training data from 3710 unique locations, landscape-level environmental drivers and a global tidal marsh extent map to produce a global, spatially explicit map of SOC storage in tidal marshes at 30 m resolution.
View Article and Find Full Text PDFFunctionalized monodisperse microbubbles have the potential to boost the sensitivity and efficacy of molecular ultrasound imaging and targeted drug delivery using bubbles and ultrasound. Monodisperse bubbles can be produced in a microfluidic flow focusing device. However, their functionalization and sequential use require removal of the excess lipids from the bubble suspension to minimize the use of expensive ligands and to avoid competitive binding and blocking of the receptor molecules.
View Article and Find Full Text PDFObjective: Immune checkpoint inhibitors (ICIs) are revolutionary in oncology but may cause immune-related (IR) side effects, such as hypophysitis. Treatment with anti-PD-(L)1, anti-CTLA-4 or anti-CLTA-4/PD-1 may induce hypophysitis, but little is known about the differences in clinical presentation or need for different treatment. We analyzed the differences of anti-PD-(L)1, anti-CTLA-4 and anti-CTLA-4/PD-1 induced hypophysitis.
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