Publications by authors named "M R Nardone"
Background: In heart failure, sympathetic excess and exercise intolerance impair quality of life. In heart failure with reduced ejection fraction, exercise stimulates a reflex increase in muscle sympathetic nerve activity (MSNA) that relates inversely to peak oxygen uptake (V̇O). Whether similar sympathoexcitatory responses are present in heart failure with preserved EF (HFpEF) and relate to V̇O are unknown.
View Article and Find Full Text PDFHuman leishmaniasis is facing important epidemiological changes in Southern Europe, driven by increased urbanization, climate changes, emerging of new animal reservoirs, shifts in human behavior and a growing population of immunocompromised and elderly individuals. In this evolving epidemiological landscape, we analyzed the clinical and epidemiological characteristics of human leishmaniasis in the Tuscany region of Central Italy. Through a multicentric retrospective analysis, we collected clinical and demographic data about all cases of leishmaniasis recorded between 2018 and 2023.
View Article and Find Full Text PDFRelationship between regional sympathetic vascular transduction and sympathetic transduction of blood pressure in young adults at rest.
Am J Physiol Regul Integr Comp Physiol
December 2024
Article Synopsis
- A study examined how bursts of muscle sympathetic nerve activity (MSNA) affect regional blood flow and overall blood pressure (BP) in 14 young adults after a meal and rest.
- Researchers recorded various metrics, including MSNA, heart rate, BP, and blood flow in the femoral artery, to analyze the relationship between changes in BP and vascular conductance.
- The findings showed that changes in BP are moderately related to regional vascular conductance, suggesting that measuring BP can provide insight into localized vascular responses to sympathetic nerve activity.
Article Synopsis
- The study investigates the reliability of blood pressure (BP) measurements during submaximal and maximal exercise, considering the potential influence of biological sex on results.
- A total of 84 participants underwent two maximal treadmill tests, with systolic BP being measured frequently and assessed for test-retest reliability using statistical methods.
- Results indicated that systolic BP reliability was substantial for both sexes during submaximal and maximal exercise, but females exhibited higher reliability compared to males, especially in submaximal conditions.
Article Synopsis
- OSAS (Obstructive Sleep Apnea Syndrome) and TMDs (Temporomandibular Disorders) are complex conditions influenced by various functional, structural, and psycho-social factors, gaining more attention in research and clinical practice.
- Recognizing the multifaceted nature of these disorders is essential, as different anatomical and phenotypic presentations may lead to inconsistent findings in the literature.
- Co-existing OSAS and TMD cases pose additional challenges for healthcare providers, emphasizing the need for collaborative research efforts to better understand and address these complex issues.