Publications by authors named "M R Narayana Murthy"

Numerous studies linking environmental pollutants to oxidative stress, inflammation, and neurotoxicity have assigned pollutants to several neurodegenerative disorders, including Alzheimer's disease (AD). Heavy metals, pesticides, air pollutants, and endocrine disruptor chemicals have been shown to play important roles in AD development, with some traditional functions in amyloid-β formation, tau kinase action, and neuronal degeneration. However, pharmacological management and supplementation have resulted in limited improvement.

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Imaging methods that span both functional measures in living tissue and anatomical measures in fixed tissue have played critical roles in advancing our understanding of the brain. However, making direct comparisons between different imaging modalities, particularly spanning living and fixed tissue, has remained challenging. For example, comparing brain-wide neural dynamics across experiments and aligning such data to anatomical resources, such as gene expression patterns or connectomes, requires precise alignment to a common set of anatomical coordinates.

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Background: Diabetes is a chronic medical condition with severe complications, mainly caused by unhealthy lifestyles in genetically susceptible individuals. There has been a growing interest in the role of mobile health technologies in achieving better self-efficacy in managing diabetes. This study attempts to assess the impact of a web-based model on improving the diabetes status among Type 2 diabetic patients attending a tertiary care hospital in southern India.

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Article Synopsis
  • The study explores the complex networks of neurons in the brain, highlighting their similarities to artificial networks and how these connections influence perception and behavior.* -
  • Researchers completed the first comprehensive wiring diagram of an adult fly's brain, consisting of over 130,000 neurons, enabling analysis of its statistical properties and structural organization.* -
  • Findings reveal that the fly brain has a "rich-club" organization with a significant number of highly connected neurons, and the data can be accessed through the FlyWire Codex for further research on neural activity and brain structure.*
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Article Synopsis
  • Neuroscience aims to create a causal model of the nervous system, and recent research on the fly connectome maps the synaptic connections between neurons but lacks details on their signaling strength in real conditions.
  • A new integrated approach combines experimental data from optogenetic perturbations with statistical methods to estimate the causal relationships in the fly brain, referred to as the 'effectome'.
  • The findings suggest that the fly’s brain dynamics are primarily governed by small, independent circuits of neurons, making it feasible to develop a causal model for its brain activity.
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