Publications by authors named "M R Meyers"
Cryptosporidiosis is a diarrheal disease caused by the parasite resulting in over 100,000 deaths annually. Here, we present a structure-activity relationship study of the benzoic acid position (R) of pyrazolo[3,4-]pyrimidine lead SLU-2815 (), an inhibitor of parasite phosphodiesterase PDE1, resulting in the discovery of benzoxaborole SLU-10906 () as a benzoic acid bioisostere. Benzoxaborole is 10-fold more potent than against the parasite in a cell-based infection model (EC = 0.
View Article and Find Full Text PDFBackground And Objectives: Studies show that new onset diabetes mellitus (DM) (NOD) predates the diagnosis of PDAC by up to 2 years. Two tumor-intrinsic molecular subtypes of PDAC that are prognostic and predictive of chemotherapy response have been described and validated. We hypothesize that patients with NOD may have different molecular subtypes and prognoses.
View Article and Find Full Text PDFPsychedelic-assisted therapy (PAT) involves supported experiences with psychedelic medicines in carefully curated environments. Early evidence suggests possible utility of PAT for addressing psychosocial-spiritual-existential concerns, yet gaps remain in understanding findings related to PAT's role in palliative care. This rapid review aims to synthesize current literature on applications of PAT in the context of palliative care.
View Article and Find Full Text PDFReliability of 4D Flow MRI for Investigation of Fetal Cardiovascular Hemodynamics in the Third Trimester.
Radiol Cardiothorac Imaging
December 2024
Article Synopsis
- The study aimed to establish reference values for fetal 4D flow MRI and assess its reliability in measuring blood flow in healthy fetuses and those with suspected aortic coarctation (CoA).
- Researchers conducted MRI scans on 34 pregnant patients, collecting data from both healthy fetuses and those with potential cardiovascular issues, analyzing the accuracy and consistency of the flow measurements obtained.
- The results indicated that fetal 4D flow MRI provides reliable hemodynamic measurements with high precision and repeatability, although it tends to underestimate blood flow compared to traditional 2D phase contrast MRI techniques.
Background: Optimal management of checkpoint inhibitor-induced complete heart block is unknown. Previous reports showed relatively high incidence of pacing failure due to the co-existing myocarditis.
Case Summary: A 71-year-old male with a prior history of stage IV metastatic squamous cell lung cancer presents was admitted for dyspnoea and hypotension 10 days after checkpoint inhibitor treatment using pembrolizumab.