Publications by authors named "M R Menard"
Objective: Wound, ischemia, and foot infection (WIfI) staging was established to provide objective classification in patients with chronic limb threatening ischemia (CLTI) and to predict 1-year major amputation risk. Our goal was to validate WIfI staging using data from the Best Endovascular versus Best Surgical Therapy in Patients with CLTI (BEST-CLI) trial.
Methods: Data from the BEST-CLI Trial, a prospective randomized trial comparing surgical (OPEN) and endovascular (ENDO) revascularization, were used to assess the association of WIfI stage on long-term outcomes in an intention to treat analysis.
Maternal Risk Conditions and Outcomes by Levels of Maternal Care.
J Womens Health (Larchmt)
October 2024
Article Synopsis
- * Using data from the National Inpatient Sample (2017-2019), the researchers focused on maternal risk factors like severe preeclampsia, placenta accreta spectrum, and cardiac issues, and examined outcomes such as serious complications and organ failures.
- * Findings indicated that risk factors were associated with worse outcomes but that these associations were less severe in higher-level care facilities (Level III/IV), suggesting that better care settings could improve maternal health results.
Abnormal accumulation of insoluble α-synuclein (α-Syn) inclusions in neurons, neurites, and glial cells is the defining neuropathology of synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy. Accumulation of α-Syn inclusions in the amygdala has been well-documented in post-mortem studies of PD and DLB brains, as well as preclinical animal models of these conditions. Though α-Syn pathology is closely associated with neurodegeneration, there is a poor correlation between neuronal loss in the amygdala and the clinical features of PD and DLB.
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- The study aimed to investigate outcomes of female patients with Critical Limb Ischemia (CLI) compared to males in the BEST-CLI trial, particularly focusing on disparities in diagnosis and treatment for peripheral artery disease.
- It analyzed male and female patients undergoing open surgical bypass or endovascular therapy, assessing outcomes like major amputation, reintervention, and all-cause death, using data from cohorts 1 and 2 of the trial.
- Results showed that females constituted only 28% of the cohort and had different clinical presentations than males, with females experiencing higher instances of rest pain and fewer adequate vein options for surgical bypass, leading to significant differences in outcomes at one year.