Publications by authors named "M R Marasco"

This article reviews the contemporary understanding of the functional role of connexins in intercellular communications, their involvement in maintaining cellular and tissue homeostasis, and in aging-associated respiratory disease pathogenesis. Connexins are discussed as potential therapeutic targets. The review particularly focuses on the involvement of gap junction connexins and hemichannels in the transfer of calcium ions, metabolite molecules, ATP, and mitochondria through the cell membrane.

View Article and Find Full Text PDF

Carcinoid syndrome (CS) is a rare condition associated with neuroendocrine tumors (NETs), particularly those originating in the gastrointestinal tract, which secrete bioactive substances like serotonin. The management of CS requires a multidisciplinary approach due to its complex clinical manifestations, including flushing, diarrhea, bronchospasm, and carcinoid heart disease. Optimal care involves collaboration between several professional figures like oncologists, endocrinologists, gastroenterologists, surgeons, and dietitians.

View Article and Find Full Text PDF
Article Synopsis
  • Overhead athletes, like those in volleyball and baseball, commonly face shoulder injuries due to limited range of motion (ROM) in the glenohumeral joint, particularly known as glenohumeral internal rotation deficit (GIRD).
  • GIRD occurs when the throwing shoulder has less internal rotation compared to the non-throwing shoulder, often caused by repetitive throwing motions leading to tightness in the posterior shoulder.
  • Osteopathic manipulative treatment (OMT), including techniques like muscle energy and myofascial release, has been shown to reduce this tightness, potentially preventing injuries and improving functionality in athletes.
View Article and Find Full Text PDF

To evaluate a radiomic strategy for predicting progression in advanced gastroenteropancreatic neuroendocrine tumor (GEP-NET) patients treated with somatostatin analogs (SSAs). Fifty-eight patients with GEP-NETs and liver metastases, with baseline computerized tomography (CT) scans from June 2013 to November 2020, were studied retrospectively. Data collected included progression-free survival (PFS), overall survival (OS), tumor grading, death, and Ki67 index.

View Article and Find Full Text PDF
Article Synopsis
  • * Research shows that NF1-null melanomas rely on RAS for growth, and using a MEK inhibitor like avutometinib alone can increase RAS signaling instead of decreasing it.
  • * Combining MEK inhibition with SOS1 suppression effectively reduces RAS activity, induces cancer cell death, and suppresses tumor growth, highlighting a new strategy for treating NF1-mutant melanoma.
View Article and Find Full Text PDF